Results 31 to 40 of about 103,612 (260)

Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies

mAbs, 2021
Understanding the pharmacokinetic (PK) properties of a drug, such as clearance, is a crucial step for evaluating efficacy. The PK of therapeutic antibodies can be complex and is influenced by interactions with the target, Fc-receptors, anti-drug ...
Boris Grinshpun, Nels Thorsteinson, Joao NS Pereira, Friedrich Rippmann, David Nannemann, Vanita D. Sood, Yves Fomekong Nanfack   +6 more
doaj   +1 more source

Mares with Delayed Uterine Clearance Have an Intrinsic Defect in Myometrial Function1 [PDF]

Biology of Reproduction, 2001
Persistent, postmating endometritis affects approximately 15% of mares and results in reduced fertility and sizable economic losses to the horse-breeding industry. Mares that are susceptible to postmating endometritis have delayed uterine clearance associated with reduced uterine contractility.
Sherri L. Rigby, Rola Barhoumi, Robert C. Burghardt, Patrick Colleran, James A. Thompson, Dickson D. Varner, Terry L. Blanchard, Steven P. Brinsko, Tex Taylor, M. Keith Wilkerson, Michael D. Delp   +10 more
openaire   +2 more sources

Function of 38 variants CYP2C9 polymorphism on ketamine metabolism in vitro

Journal of Pharmacological Sciences, 2017
Background: Cytochrome P450 proteins (CYP 450) is the most important enzyme system of drug phase I metabolism in liver. In previous reports, reduced efficiency or increased risk of adverse events can be affected by primary sequence mutation in CYP450 ...
Xiang Zheng, Ping Fang, Su-su Bao, Dan Lin, Jian-ping Cai, Guo-xin Hu   +5 more
doaj   +1 more source

In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species

Frontiers in Pharmacology, 2020
Liver S9 (LS9) is a nearly complete collection of all hepatic drug-metabolizing enzymes. It is a low-cost model for predicting drug metabolic activity.
Ponsiree Jithavech, Ponsiree Jithavech, Pahweenvaj Ratnatilaka Na Bhuket, Wiwat Supasena, Guanyinsheng Qiu, Shengqing Ye, Jie Wu, Tin Wui Wong, Pornchai Rojsitthisak, Pornchai Rojsitthisak   +9 more
doaj   +1 more source

Determination of single-molecule transport activity of OATP2B1 by measuring the number of transporter molecules using electrophysiological approach

Journal of Pharmacological Sciences, 2023
Transporter-mediated clearance is determined by two factors, its single-molecule clearance, and expression level. However, no reliable method has been developed to evaluate them separately. This study aimed to develop a reliable method for evaluating the
Kodai Yajima, Takeshi Akiyoshi, Kazuho Sakamoto, Yoshiaki Suzuki, Takayuki Oka, Ayuko Imaoka, Hisao Yamamura, Junko Kurokawa, Hisakazu Ohtani   +8 more
doaj   +1 more source

Metabolic clearance of select opioids and opioid antagonists using hepatic spheroids and recombinant cytochrome P450 enzymes

Pharmacology Research & Perspectives, 2022
The opioid crisis is a pressing public health issue, exacerbated by the emergence of more potent synthetic opioids, particularly fentanyl and its analogs.
Wing Y. Tuet, Samuel A. Pierce, Matthieu Conroy, Justin N. Vignola, Justin Tressler, Robert C. diTargiani, Bryan J. McCranor, Benjamin Wong   +7 more
doaj   +1 more source

In Vitro Pharmacokinetic Behavior of Antiviral 3-Amidinophenylalanine Derivatives in Rat, Dog and Monkey Hepatocytes

Biomedicines, 2023
Type II transmembrane serine proteases represent pharmacological targets for blocking entry and spread of influenza or coronaviruses. In this study, the depletion rates of the 3-amidinophenylalanine (3-APhA)-derived matriptase/TMPRSS2 inhibitors MI-463 ...
Katalin Lányi, Katalin Monostory, Torsten Steinmetzer, Ákos Jerzsele, Erzsébet Pászti-Gere   +4 more
doaj   +1 more source

Interpretation of multi-task clearance models from molecular images supported by experimental design

Artificial Intelligence in the Life Sciences, 2022
Recent methodological advances in deep learning (DL) architectures have not only improved the performance of predictive models but also enhanced their interpretability potential, thus considerably increasing their transparency.
Andrés Martínez Mora, Mickael Mogemark, Vigneshwari Subramanian, Filip Miljković   +3 more
doaj   +1 more source

Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18.

PLoS Pathogens, 2020
Intestinal epithelial cells (IECs) are at the forefront of host-pathogen interactions, coordinating a cascade of immune responses to protect against pathogens.
Namrata Iyer, Mayara Grizotte-Lake, Kellyanne Duncan, Sarah R Gordon, Ana C S Palmer, Crystle Calvin, Guo Zhong, Nina Isoherranen, Shipra Vaishnava   +8 more
doaj   +1 more source

The HIT Network for Children and Adolescents With CNS Tumors Facilitates Improvements of Diagnostic Assessments, Multimodal Treatments, Individual Counseling, and Research in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski, Michael C. Frühwald, Gudrun Fleischhack, Stephan Tippelt, Pablo Hernáiz‐Driever, Olaf Witt, Astrid Gnekow, Christof Kramm, Matthias Eyrich, Johannes E. A. Wolf, Hermann Müller, Carsten Friedrich, Uwe R. Kordes, Denise Obrecht‐Sturm, Petra Ketteler, Barbara von Zezschwitz, Pascal Johann, Dominik Sturm, Karoline Nemes, Stefan Schönberger, Till Milde, Brigitte Bison, Monika Warmuth‐Metz, Torsten Pietsch, Ulrich Schüller, Arend Koch, David Capper, Martin Hasselblatt, Christian Thomas, Christian Hagel, Stefan M. Pfister, Felix Sahm, David T. W. Jones, Martin U. Schuhmann, Jürgen Krauss, Pedram Emami, Ahmed El Damaty, Rolf D. Kortmann, Rudolf Schwarz, Jürgen Debus, Mechthild Krause, Fabian Pohl, Holger Ottensmeier, Lisa Bußenius, Katja Baust, Andreas Faldum, Cecile Ronckers, Desiree Grabow, Martin Benesch, Thomas Perwein, Karin Dieckmann, Irene Slavc, Johannes Gojo, Nicolas U. Gerber, André O. von Bueren, Katrin Scheinemann, Gabriele Calaminus, Beate Timmermann, Ulrich‐Wilhelm Thomale, Martin Mynarek   +59 more
wiley   +1 more source