Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Preferensi Motivasi Intrinsik Pada Volunteer Di Indonesia International Workcamp [PDF]
, 2014 Intrinsic motivation has several factors (instrument) contained on it There are 4 factors on intrinsic motivation which is owned by the volunteers were examined in this study, the factors are advancement, recognition, achievement and responsibility ...
DARMASTUTI , Ismi +1 more
core
VLBI observations of seven BL Lac objects from RGB sample
, 2007 We present EVN observations of seven BL Lac objects selected from the RGB sample. To investigate the intrinsic radiation property of BL Lac objects, we estimated the Doppler factor with the VLA or MERLIN core and the total 408 MHz luminosity for a sample
Albert +61 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Inhibition of Factor XI Using RBD4059
JACC: Basic to Translational ScienceSummary: Coagulation factor XI (FXI) is an attractive target for novel antithrombotic drugs because of its minor role in hemostasis, which may address the current unmet medical need regarding a powerful anticoagulant with low bleeding risk.
Junshi Liang, MSc +13 more
doaj +1 more source
Intrinsic electronic transport and thermoelectric power factor in n-type doped monolayer MoS2
New Journal of Physics, 2018 The electronic transport and thermoelectric properties in n -type doped monolayer MoS _2 are investigated by a parameter-free method based on first-principles calculations, electron–phonon coupling (EPC), and Boltzmann transport equation (BTE ...
Yinchang Zhao +7 more
doaj +1 more source
Analysis of equivalent circuit of test of intrinsic safety circuit
Gong-kuang zidonghua, 2013 Taking an intrinsic safety circuit of passive rescue telephone as an example, the paper analyzed test process of safe spark test of the circuit under different electrical principle equivalent diagrams of intrinsic safety test, and indicated that spark ...
LIU Qi
doaj +1 more source
Analysis of enterotoxin production by Staphylococcus aureus in Minas Frescal Cheese under different intrinsic and extrinsic factors [PDF]
, 2020 Nathália Cristina Cirone Silva +6 more
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
Cells, 2018 Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms.
Bernhard Englinger +10 more
doaj +1 more source