Results 81 to 90 of about 15,218,319 (382)
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
SAGE Open Medical Case ReportsMegaloblastic anaemia is mainly caused by vitamin B12 or folate deficiency. However, rare cases present with discordant laboratory findings, particularly falsely elevated vitamin B12 levels due to assay interference from anti-intrinsic factor antibodies,
Mohammed Abdulgayoom +6 more
doaj +1 more source
Analysis of equivalent circuit of test of intrinsic safety circuit
Gong-kuang zidonghua, 2013 Taking an intrinsic safety circuit of passive rescue telephone as an example, the paper analyzed test process of safe spark test of the circuit under different electrical principle equivalent diagrams of intrinsic safety test, and indicated that spark ...
LIU Qi
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
Cells, 2018 Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms.
Bernhard Englinger +10 more
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Relationship between Identity Styles with Motivation Factors and Success Feeling [PDF]
مدیریت بهره وری, 2009 The purpose of this study was to determine the relationship between identity styles and motivation factors and success feeling in the elite teenager male soccer and karate players.
Jafar Barghi Moghaddam +3 more
doaj
Intrinsic electronic transport and thermoelectric power factor in n-type doped monolayer MoS2
New Journal of Physics, 2018 The electronic transport and thermoelectric properties in n -type doped monolayer MoS _2 are investigated by a parameter-free method based on first-principles calculations, electron–phonon coupling (EPC), and Boltzmann transport equation (BTE ...
Yinchang Zhao +7 more
doaj +1 more source