Results 1 to 10 of about 99,304 (165)

Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis. [PDF]

Cell Rep, 2018
The effector B cell lymphoma-2 (BCL-2) protein BCL-2 ovarian killer (BOK) induces mitochondrial outer membrane permeabilization (MOMP) to initiate apoptosis upon inhibition of the proteasome. How BOK mediates MOMP is mechanistically unknown. The NMR structure of the BCL-2 core of human BOK reveals a conserved architecture with an atypical hydrophobic ...
Zheng JH, Grace CR, Guibao CD, McNamara DE, Llambi F, Wang YM, Chen T, Moldoveanu T.   +7 more
europepmc   +3 more sources

Soft Tissue Stabilization of Midcarpal Instability in Ehlers–Danlos Patients Using a Cadaveric Tendon Graft [PDF]

Plastic and Reconstructive Surgery, Global Open
Summary:. Ehlers–Danlos syndrome (EDS) is a group of hereditary disorders that affects collagen synthesis. In the wrist, pain and midcarpal laxity may affect up to 70% of EDS patients.
Mohammed Muneer, MD, Fadi Bouri, MBBS, Kjell Van Royen, MD, Saif Badran, MD, Jorge I. Quintero, MD, MHPE, Tuna Ozyurekoglu, MD   +5 more
doaj   +2 more sources

Genome instability and crosstalk with the immune response [PDF]

Genome Medicine
Genome instability, tumour-promoting inflammation, and immune escape are three distinct hallmarks of cancer. However, accumulating scientific and clinical evidence over the past decade have uncovered a multifaceted interplay of complex dynamic network of
Roman M. Chabanon, François-Xavier Danlos, Kaissa Ouali, Sophie Postel-Vinay   +3 more
doaj   +2 more sources

Dynamic behavior and flame acceleration of spherically expanding hydrogen flames under the low-pressure conditions

Nihon Kikai Gakkai ronbunshu, 2023
To investigate the dynamic behavior and flame acceleration of spherically expanding hydrogen flames under the low-pressure conditions, the deflagration experiments were conducted in a closed combustion chamber. The dynamic behavior of hydrogen flames was
Toshiyuki KATSUMI, Shinya YAZAWA, Masashi KUMADA, Daisuke SATO, Satoshi KADOWAKI   +4 more
doaj   +1 more source

The effects of addition of carbon dioxide and water vapor on the dynamic behavior of spherically expanding hydrogen/air premixed flames

Journal of Thermal Science and Technology, 2021
Utilizing efficiently and securely hydrogen as clean energy source, it is required not only to analyze the experimental data under a certain condition but also to create the mathematical model for the prediction of flame propagation velocity under ...
Toshiyuki KATSUMI, Yasuhito YOSHIDA, Ryo NAKAGAWA, Shinya YAZAWA, Masashi KUMADA, Daisuke SATO, Thwe Thwe Aung, Nabiha CHAUMEIX, Satoshi KADOWAKI   +8 more
doaj   +1 more source

INTRINSIC INSTABILITY OF CORONAL STREAMERS [PDF]

The Astrophysical Journal, 2009
Plasma blobs are observed to be weak density enhancements as radially stretched structures emerging from the cusps of quiescent coronal streamers. In this paper, it is suggested that the formation of blobs is a consequence of an intrinsic instability of coronal streamers occurring at a very localized region around the cusp.
Chen, Y., Li, X., Song, H. Q., Shi, Q. Q., Feng, S. W., Xia, L. D.   +5 more
openaire   +2 more sources

Effects of pressure and heat loss on the unstable motion of cellular-flame fronts caused by intrinsic instability in hydrogen-air lean premixed flames

Journal of Thermal Science and Technology, 2021
Effects of pressure and heat loss on the unstable motion of cellular-flame fronts in hydrogen-air lean premixed flames were numerically investigated. We adopted the reaction mechanism for hydrogen-oxygen combustion, modeled with seventeen reversible ...
Satoshi KADOWAKI, Thwe Thwe Aung, Taisei FURUYAMA, Kazumasa KAWATA, Toshiyuki KATSUMI, Hideaki KOBAYASHI   +5 more
doaj   +1 more source

The shape and fluctuation of hydrogen-propane-butane-air lean premixed flames formed on a flat flame burner

Journal of Thermal Science and Technology, 2021
In this paper, the characteristics of hydrogen-propane-butane-air lean premixed flames on a flat flame burner were experimentally studied. To elucidate the shape and fluctuation of premixed flames, the cell width, RMS of fluctuation, peak frequency and ...
Satoshi NAKATSURU, Amornrat KAEWPRADAP, Ryosuke NOGI, Toshiyuki KATSUMI, Daisuke SATO, Satoshi KADOWAKI   +5 more
doaj   +1 more source

Chromosomal Instability Confers Intrinsic Multidrug Resistance [PDF]

Cancer Research, 2011
Abstract Aneuploidy is associated with poor prognosis in solid tumors. Spontaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) that may contribute to the acquisition of multidrug resistance in vitro and heighten risk for tumor relapse in animal models.
Alvin J X, Lee, David, Endesfelder, Andrew J, Rowan, Axel, Walther, Nicolai J, Birkbak, P Andrew, Futreal, Julian, Downward, Zoltan, Szallasi, Ian P M, Tomlinson, Michael, Howell, Maik, Kschischo, Charles, Swanton   +11 more
openaire   +2 more sources

Intrinsic Instability of Aberration-Corrected Electron Microscopes [PDF]

Physical Review Letters, 2012
Aberration-corrected microscopes with sub-atomic resolution will impact broad areas of science and technology. However, the experimentally observed lifetime of the corrected state is just a few minutes. Here we show that the corrected state is intrinsically unstable; the higher its quality, the more unstable it is.
Schramm, S., Molen, S.J. van der, Tromp, R.M.   +2 more
openaire   +4 more sources