Results 91 to 100 of about 215,660 (296)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Estimation the wear state of milling tools using a combined ensemble empirical mode decomposition and support vector machine method

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
Vibrational signals resulting from tool wear have non-linear and non-stationary features. It is also difficult to acquire large numbers of typically worn samples in practice.
Chuangwen XU, Yuzhen CHAI, Huaiyuan LI, Zhicheng SHI   +3 more
doaj   +1 more source

Hardware design of Foundation Fieldbus intrinsic safety communication protocol processing unit

, 2006
In this paper, the key technology of hardware design on the communication protocol processing unit is given from the views of the system function, resource requirement, power consumption limit, signal transmission, processing speed and power supply mode ...
Wang Hong, Wang Ying, Cui Shu-ping, Cui SP(崔书平), Wang Y(汪滢), Wang H(王宏)   +5 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Chatter Identification of Three-Dimensional Elliptical vibration Cutting Process Based on Empirical Mode Decomposition and Feature Extraction

Applied Sciences, 2018
Three-dimensional elliptical vibration cutting (3D-EVC) is one of the machining methods with the most potential in ultra-precision machining; its unique characteristics of intermittent cutting, friction reversal, and ease of chip removal can improve the ...
Mingming Lu, Bin Chen, Dongpo Zhao, Jiakang Zhou, Jieqiong Lin, Allen Yi, Hao Wang   +6 more
doaj   +1 more source

Mimicking a hybrid-optomechanical system using an intrinsic quadratic coupling in conventional optomechanical system

, 2019
We consider an optical and mechanical mode interacting through both linear and quadratic dispersive couplings in a general cavity-optomechanical set-up.
Kumar, M Anil, Sainadh, U Satya
core   +1 more source

Speech enhancement using adaptive thresholding based on gamma distribution of Teager energy operated intrinsic mode functions [PDF]

, 2019
This paper introduces a new speech enhancement algorithm based on the adaptive threshold of intrinsic mode functions (IMFs) of noisy signal frames extracted by empirical mode decomposition.
Arslan, Ozkan, Engin, Erkan Zeki
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Anisotropy of Earth's inner core intrinsic attenuation from seismic normal mode models

, 2014
The Earth's inner core, the slowly growing sphere of solid iron alloy at the centre of our planet, is known to exhibit seismic anisotropy. Both normal mode and body wave studies have established that, when the global average is taken, compressional waves
Deuss, Arwen, Mäkinen, Anna M, Redfern, Simon A. T.   +2 more
core   +2 more sources

Intrinsic Pink-Noise Multidecadal Global Climate Dynamics Mode

, 2018
Understanding multidecadal variability is an essential goal of climate dynamics. For example, the recent phenomenon referred to as the global warming hiatus may reflect a coupling to an intrinsic, preindustrial, multidecadal variability process.
Agarwal, Sahil, Moon, Woosok, Agarwal, Sahil,, Wettlaufer, John S.,, Moon, Woosok,, Wettlaufer, John S.   +5 more
core   +1 more source