Results 41 to 50 of about 197,579 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Storage tank maintenance strategy in oil storage

You-qi chuyun, 2023
As the most important static equipment in oil storage, atmospheric pressure storage tanks, in the long course of time under the influence of the environment, external forces, and the force of different mediums, are apt to meet the problems of partial ...
QU Jianjun, JI Ruijun
doaj   +1 more source

Evaluation and Improvement of the Intrinsic Safety Level of Employees

Journal of Physics: Conference Series, 2021
Abstract Intrinsic safety is the eternal pursuit of power companies. The intrinsic safety level of front-line employees of technical skills posts is the basic guarantee for the security and stability operation of power systems. In order to help power companies scientifically evaluate and effectively improve the intrinsic safety level of ...
Jing Zhang, Xiaonuo Zhang, Yan Yi
openaire   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Influence of parameters and optimization on flow heat transfer and particle deposition in twisted elliptical tubes

Case Studies in Thermal Engineering
Twisted elliptical tubes (TETs) are promising for heat exchanger applications due to their enhanced heat transfer capability, but the deposition characteristics of particles within their structure remain unclear.
Wei Lin, Haodong Yu, Xin Wen, Junwen Cheng, Shengjie Yang, Cheng Gong, Qunyu Tang, Tangzhengzheng Tang, Jin Cao, Hong Tang, Wei Wang, Jiuyang Yu   +11 more
doaj   +1 more source

Research on explosion-proof technology for coal mine rescue robot

Gong-kuang zidonghua, 2019
The paper introduced general situation of explosion-proof technology of coal mine rescue robot, and summarized the research status and application of explosion-proof technology of coal mine rescue robot at home and abroad, and pointed out some progress ...
ZHENG Xuezhao, YAN Xing, GUO Jun, ZHANG Duo   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Research on surge protection technology of coal mine safety monitoring system

Gong-kuang zidonghua, 2018
The conventional surge protection technology was introduced. Based on theoretical research and standard test of electromagnetic compatibility surge protection technology in coal mine safety monitoring system, it was indicated that the conventional surge ...
ZHANG Ziliang
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Exergy-based ecological performance analyses and multi-objective optimizations for an endoreversible three-reservoir chemical potential transformer

Case Studies in Thermal Engineering
In this paper, exergy-based ecological-function (ECF) optimal performances for endoreversible three-reservoir chemical potential (CHP) transformer with linear and diffusive mass transfer (MT) laws are studied.
Shuangshuang Shi, Lingen Chen, Yanlin Ge, Huijun Feng   +3 more
doaj   +1 more source