Results 101 to 110 of about 1,852,727 (295)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Retention Intention of Chinese Urban Preschool Teachers Predicted by Workload and Work Value

SAGE Open
Given the need to guarantee sustainable, high-quality preschool education and considering preschool teachers’ central role in children’s learning and growth, the effective development of preschool teachers requires serious attention.
Li Cheng, Kimberly Phillips, Xiangting He   +2 more
doaj   +1 more source

Factors Associated with Work Motivation For Hospital Nurses: A scoping review

Asia Pacific Journal of Health Management
Introduction: The performance and quality levels of care by the nursing service system depends on the motivation levels of nurses. The aim of this research is to map the factors related to the work motivation of nurses in hospitals.
Muhammad Fahresi Kamirullah, Atjo Wahyu, Stang Stang, Muhammad Furqaan Naiem, Rafael Djajakusli, Amran Razak, Andi Agus Mumang   +6 more
doaj   +1 more source

On Spin Dependence of Relativistic Acoustic Geometry

, 2012
This work makes the first ever attempt to understand the influence of the black hole background space-time in determining the fundamental properties of the embedded relativistic acoustic geometry.
Chang, Hsiang-Kuang, Das, Tapas Kumar, Maiti, Ishita, Pu, Hung-Yi   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

FAKTOR-FAKTOR YANG MEMPENGARUHI MAHASISWA AKUNTANSI DALAM PEMILIHAN KARIR MENJADI AKUNTAN PUBLIK (Studi Empiris pada Mahasiswa Akuntansi UNDIP dan Mahasiswa Akuntansi UNIKA) [PDF]

, 2011
The purpose of this study is to investigate and analyze the factors that influence accounting students in the selection of a public accounting career.
APRILYAN, Lara Absara, LAKSITO, Herry
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Who works in the public sector? Evidence from the World Values Survey [PDF]

Earlier single-country studies found a higher level of intrinsic motivation among public sector workers, compared to the private sector. Using data from the World Values Survey, covering 51 countries, we find a tendency for public sector workers to be ...
Edd Cowley, Sarah Smith
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source