Results 111 to 120 of about 41,661 (301)

Understanding β-strand mediated protein-protein interactions using peptidomimetics: tuning binding affinity of intrinsically disordered sequences by covalent backbone modification

, 2023
A significant challenge in chemical biology is to understand and modulate protein-protein interactions (PPIs). Given that many PPIs involve a folded protein domain and a peptide sequence that is intrinsically disordered in isolation, peptides represent ...
Thomas, Edwards, Wilson, Andrew, Emma, Cawood, Theodoros , Karamanos, Emily, Baker, Derek, Woolfson   +5 more
core   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

Intrinsically Disordered Proteins

Current Science, 2018
The Indian Institute of Science Education and Research Mohali, marked its tenth year of establishment by organizing an international conference on intrinsically disordered proteins (IDPs). IDPs are a functionally important class of proteins involved in a wide spectrum of physiological functions and human diseases like Alzheimer’s and Parkinson’s ...
openaire   +2 more sources

Emergence and evolution of an interaction between intrinsically disordered proteins

eLife, 2017
Protein-protein interactions involving intrinsically disordered proteins are important for cellular function and common in all organisms. However, it is not clear how such interactions emerge and evolve on a molecular level.
Greta Hultqvist, Emma Åberg, Carlo Camilloni, Gustav N Sundell, Eva Andersson, Jakob Dogan, Celestine N Chi, Michele Vendruscolo, Per Jemth   +8 more
doaj   +1 more source

Direct Metal Deposition of Graphene–Ti28Nb35.4Zr Matrix Composites With Enhanced Mechanical, Corrosion, and Biocompatibility Properties for Bone Implants

Advanced Engineering Materials, EarlyView.
Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir, Jixing Lin, Yuncang Li, Li Zhu, Paul F. A. Wright, Cuie Wen   +5 more
wiley   +1 more source

Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain

, 2018
Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on
Matthew, Francis, Matthew J., Smith, Anthony, Omole, Kenneth, Downing, Jessica, Lee, Sarah, Klass, Tahoe, Fiala   +6 more
core   +1 more source

Near‐Infrared Light‐Driven Zn/Au Janus Micromotors for Multiplex SERS Detection of Anticancer Drugs

Advanced Functional Materials, EarlyView.
Zn/Au Janus micromotors, propelled by thermophoretic effects under NIR light, function as active SERS platforms for single and multiplex detection of anticancer drugs. Their dynamic motion enhances analyte exchange at the Au interface, reducing saturation and competitive adsorption, thereby improving sensitivity and extending the linear detection range.
Tijana Maric, Gohar Soufi, Ziqiao Li, Erick Chica, Amran Abdirasheed Ali Jinow, Nada Al‐Roubaï, Noor Ahmed, Yaman Göksel, Anja Boisen   +8 more
wiley   +1 more source

Editorial: Intrinsically Disordered Proteins and Regions: The Challenge to the Structure-Function Relationship

Frontiers in Molecular Biosciences, 2022
Angelo Toto, Pietro Sormanni, Cristina Paissoni, Vladimir N. Uversky   +3 more
doaj   +1 more source

Contribution of protein phosphorylation to binding-induced folding of the SLBP–histone mRNA complex probed by phosphorus-31 NMR

FEBS Open Bio, 2014
Phosphorus-31 (31P) NMR can be used to characterize the structure and dynamics of phosphorylated proteins. Here, I use 31P NMR to report on the chemical nature of a phosphothreonine that lies in the RNA binding domain of SLBP (stem-loop binding protein).
Roopa Thapar
doaj   +1 more source

Deciphering the mechanisms of binding induced folding at nearly atomic resolution : The Φ value analysis applied to IDPs

, 2014
The Φ value analysis is a method to analyze the structure of metastable states in reaction pathways. Such a methodology is based on the quantitative analysis of the effect of point mutations on the kinetics and thermodynamics of the probed reaction.
Gianni, Stefano, Jemth, Per, Dogan, Jakob, Dogan, Jakob,, Jemth, Per,   +4 more
core   +1 more source