Results 121 to 130 of about 3,841,423 (288)

Human long intrinsically disordered protein regions are frequent targets of positive selection [PDF]

, 2018
Intrinsically disordered regions occur frequently in proteins and are characterized by a lack of a well-defined three-dimensional structure. Although these regions do not show a higher-order of structural organization, they are known to be functionally ...
Mathias Bockwoldt, Bockwoldt, M., Cooney, Christopher, Afanasyeva, A., Christopher R. Cooney, Bockwoldt, Mathias, Cooney, Christopher R., Heiland, Ines, Gossmann, Toni Ingolf, Toni I. Gossmann, Heiland, I., Gossmann, T., Afanasyeva, Arina, Ines Heiland, Cooney, C., Arina Afanasyeva, Goßmann, Toni ; https://orcid.org/   +16 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

[Intrinsically disordered proteins].

Postepy biochemii, 2012
Intrinsically disordered proteins (IDPs) belong to the newly discovered and still growing group of proteins. In contrast to globular proteins IDPs fail to fold into a well-defined tertiary structure under physiological conditions and they are characterized by extraordinary structural flexibility and plasticity.
Agnieszka, Dziedzic-Letka, Andrzej, Ozyhar   +1 more
openaire   +3 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Intrinsically Disordered Proteins

Current Science, 2018
The Indian Institute of Science Education and Research Mohali, marked its tenth year of establishment by organizing an international conference on intrinsically disordered proteins (IDPs). IDPs are a functionally important class of proteins involved in a wide spectrum of physiological functions and human diseases like Alzheimer’s and Parkinson’s ...
openaire   +2 more sources

Diffusion of intrinsically disordered proteins within protein condensates

Physical Review Research
Many intrinsically disordered proteins (IDPs) may undergo a phase separation to form a biomolecular condensate. Understanding the behavior of individual molecules within condensates is crucial for characterizing their collective physical properties ...
Fuga Watanabe, Takuma Akimoto, Robert B. Best, Kresten Lindorff-Larsen, Ralf Metzler, Eiji Yamamoto   +5 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Thermoresponsive intrinsically disordered protein polymers

Thermoresponsive intrinsically disordered protein polymers (TIDPPs) are a unique class of biopolymers that lack a fixed three-dimensional structure under physiological conditions and exhibit temperature-responsive behavior. These properties are primarily
Uversky, Vladimir N., Tripathi, Timir, Coskuner-Weber, Orkid   +2 more
core   +1 more source