Results 241 to 250 of about 3,587,930 (291)

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

IDP-EDL: enhancing intrinsically disordered protein prediction by combining protein language model and ensemble deep learning. [PDF]

Brief Bioinform
Xie J, Jin X, Wei H, Sun S, Liu Y.
europepmc   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Self-association and multimer formation in AtLEA4-5, a desiccation-induced intrinsically disordered protein from plants. [PDF]

Protein Sci
Romero-Pérez PS, Martínez-Castro LV, Linares A, Arroyo-Mosso I, Sánchez-Puig N, Cuevas-Velazquez CL, Sukenik S, Guerrero A, Covarrubias AA.   +8 more
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

AlphaFold2 modeling and molecular dynamics simulations of an intrinsically disordered protein. [PDF]

PLoS One
Guo HB, Huntington B, Perminov A, Smith K, Hastings N, Dennis P, Kelley-Loughnane N, Berry R.   +7 more
europepmc   +1 more source

Encoding Structure in Intrinsically Disordered Protein Biomaterials. [PDF]

Acc Chem Res
Strader RL, Shmidov Y, Chilkoti A.
europepmc   +1 more source

Conserved and repetitive motifs in an intrinsically disordered protein drive ⍺-carboxysome assembly. [PDF]

J Biol Chem
Turnšek JB, Oltrogge LM, Savage DF.
europepmc   +1 more source

Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca ²⁺ signaling

Kumar S, Gunaratne GS, Cornish J, Silvey KM, Mu Q, Guan Z, Heller GT, Slama JT, Patel S, Marchant JS.   +9 more
europepmc   +1 more source

The Wheat Intrinsically Disordered Protein <i>Td</i>RL1 Negatively Regulates the Type One Protein Phosphatase <i>Td</i>PP1. [PDF]

Biomolecules
Amor F, Bradai M, Zaidi I, Amorim-Silva V, Miled N, Hanin M, Ebel C.   +6 more
europepmc   +1 more source