Results 261 to 270 of about 3,587,930 (291)

Translocation of polyampholytes and intrinsically disordered proteins⋆

The European Physical Journal E, 2018
Polyampholytes are polymers carrying electrical charges of both signs along their backbone. We consider synthetic polyampholytes with a quenched random charge sequence and intrinsically disordered proteins, which have a well-defined charge sequence and behave like polyampholytes in the denaturated state.
Johner, Albert, Joanny, Jean-François
openaire   +3 more sources

Intrinsically disordered proteins: regulation and disease

Current Opinion in Structural Biology, 2011
Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions because disordered segments permit interaction with several proteins and hence the re-use of the same protein in multiple pathways. Understanding IDP regulation is important because altered expression of IDPs is associated with many diseases. Recent studies show
Babu, M.M., Lee, R.T.J.G. van der, Groot, N.S. de, Gsponer, J.   +3 more
openaire   +2 more sources

Druggability of Intrinsically Disordered Proteins

2015
Although the proteins in all the current major classes considered to be druggable are folded in their native states, intrinsically disordered proteins (IDPs) are becoming attractive candidates for therapeutic intervention by small drug-like molecules.
Priyanka, Joshi, Michele, Vendruscolo
openaire   +2 more sources

Intrinsically disordered proteins

This chapter explores intrinsically disordered proteins (IDPs), detailing their discovery, structural characteristics, and indispensable biological functions. It introduces the hypothesis that unfolded proteins can bind diverse partners, first proposed in 1939, and follows the experimental validation of IDPs using NMR and X-ray methods.
openaire   +2 more sources

Intrinsic Disorder and Protein Function

Biochemistry, 2002
A Keith, Dunker, Celeste J, Brown, J David, Lawson, Lilia M, Iakoucheva, Zoran, Obradović   +4 more
openaire   +2 more sources

The molecular basis for cellular function of intrinsically disordered protein regions

Nature Reviews Molecular Cell Biology, 2023
Alex Holehouse, Birthe Kragelund
exaly  

Impact of In‐Cell and In‐Vitro Crowding on the Conformations and Dynamics of an Intrinsically Disordered Protein

Angewandte Chemie - International Edition, 2021
Andrea Soranno, Benjamin Schüler, Iwo König   +2 more
exaly  

Experimentally Determined Long Intrinsically Disordered Protein Regions Are Now Abundant in the Protein Data Bank

International Journal of Molecular Sciences, 2020
Damiano Piovesan, Marco Necci, Federica Quaglia   +2 more
exaly  

Intrinsically disordered proteins in cellular signalling and regulation

Nature Reviews Molecular Cell Biology, 2014
H Jane Dyson, Peter Wright
exaly  

Intrinsically Disordered Protein TEX264 Mediates ER-phagy

Molecular Cell, 2019
Tohru Natsume, Noboru Mizushima, Haruka Chino   +2 more
exaly