Results 261 to 270 of about 3,841,423 (288)

Intrinsically disordered proteins: regulation and disease

Current Opinion in Structural Biology, 2011
Intrinsically disordered proteins (IDPs) are enriched in signaling and regulatory functions because disordered segments permit interaction with several proteins and hence the re-use of the same protein in multiple pathways. Understanding IDP regulation is important because altered expression of IDPs is associated with many diseases. Recent studies show
Babu, M.M., Lee, R.T.J.G. van der, Groot, N.S. de, Gsponer, J.   +3 more
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Druggability of Intrinsically Disordered Proteins

2015
Although the proteins in all the current major classes considered to be druggable are folded in their native states, intrinsically disordered proteins (IDPs) are becoming attractive candidates for therapeutic intervention by small drug-like molecules.
Priyanka, Joshi, Michele, Vendruscolo
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Intrinsically disordered proteins

This chapter explores intrinsically disordered proteins (IDPs), detailing their discovery, structural characteristics, and indispensable biological functions. It introduces the hypothesis that unfolded proteins can bind diverse partners, first proposed in 1939, and follows the experimental validation of IDPs using NMR and X-ray methods.
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Intrinsic Disorder and Protein Function

Biochemistry, 2002
A Keith, Dunker, Celeste J, Brown, J David, Lawson, Lilia M, Iakoucheva, Zoran, Obradović   +4 more
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Impact of In-Cell and In-Vitro Crowding on the Conformations and Dynamics of an Intrinsically Disordered Protein

Angewandte Chemie - International Edition, 2021
Andrea Soranno, Benjamin Schuler, Iwo König   +2 more
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Intrinsically Disordered Proteins in Cellular Signalling and Regulation

Nature Reviews Molecular Cell Biology, 2015
Helen Jane Dyson, Peter Wright
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The Entropic Force Generated by Intrinsically Disordered Segments Tunes Protein Function

Nature, 2018
Stephen C Harvey, Robert S. Phillips, Nicholas D Keul   +2 more
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Disordered Interactions

Nature Reviews Molecular Cell Biology, 2018
Paulina Strzyz
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Intrinsically disordered proteins

Journal of Molecular Graphics and Modelling, 2000
A.A Keith Dunker, Jeong Oh, Christopher Oldfield, Pedro Romero, Catherine Ratliff, Kerry W. Hipps, Raymond Reeves, Juan Ausio, Charles Kissinger, Robert Bailey, Michael Griswold, Celeste J. Brown, Wah Chiu, Zoran Obradovic   +13 more
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Investigation of Intrinsically Disordered Proteins Through Exchange With Hyperpolarized Water

Angewandte Chemie - International Edition, 2017
Dennis Kurzbach, Robert Konrat, Geoffrey Bodenhausen   +2 more
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