Results 81 to 90 of about 3,841,423 (288)

Elucidating ATP’s role as solubilizer of biomolecular aggregate

eLife
Proteins occurring in significantly high concentrations in cellular environments (over 100 mg/ml) and functioning in crowded cytoplasm, often face the prodigious challenges of aggregation which are the pathological hallmark of aging and are critically ...
Susmita Sarkar, Saurabh Gupta, Chiranjit Mahato, Dibyendu Das, Jagannath Mondal   +4 more
doaj   +1 more source

Development of Charge-Augmented Three-Point Water Model (CAIPi3P) for Accurate Simulations of Intrinsically Disordered Proteins [PDF]

, 2019
Intrinsically disordered proteins (IDPs) are molecules without a fixed tertiary structure, exerting crucial roles in cellular signalling, growth and molecular recognition events. Due to their high plasticity, IDPs are very challenging in experimental and
Agnieszka K., Bronowska, Joao Victor, de Souza Cunha, Francesc, Sabanes Zariquiey   +2 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Ensemble Docking for Intrinsically Disordered Proteins

Journal of Chemical Information and Modeling
Abstract Intrinsically disordered proteins (IDPs) are implicated in many human diseases and are increasingly being pursued as drug targets. Conventional structure-based drug design methods that rely on well-defined binding sites are however, largely unsuitable for IDPs.
Anjali Dhar, Thomas R. Sisk, Paul Robustelli   +2 more
openaire   +3 more sources

Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell.

PLoS ONE, 2019
Many studies about classification and the functional annotation of intrinsically disordered proteins (IDPs) are based on either the occurrence of long disordered regions or the fraction of disordered residues in the sequence.
Antonio Deiana, Sergio Forcelloni, Alessandro Porrello, Andrea Giansanti   +3 more
doaj   +1 more source

Evaluation of sequence features from intrinsically disordered regions for the estimation of protein function.

PLoS ONE, 2014
With the exponential increase in the number of sequenced organisms, automated annotation of proteins is becoming increasingly important. Intrinsically disordered regions are known to play a significant role in protein function.
Alok Sharma, Abdollah Dehzangi, James Lyons, Seiya Imoto, Satoru Miyano, Kenta Nakai, Ashwini Patil   +6 more
doaj   +1 more source

New insights into disordered proteins and regions according to the FOD-M model.

PLoS ONE, 2022
A collection of intrinsically disordered proteins (IDPs) having regions with the status of intrinsically disordered (IDR) according to the Disprot database was analyzed from the point of view of the structure of hydrophobic core in the structural unit ...
Irena Roterman, Katarzyna Stapor, Piotr Fabian, Leszek Konieczny   +3 more
doaj   +1 more source

SCREENING INTERACTIONS BETWEEN PROTEINS AND DISORDERED PEPTIDES BY A NOVEL COMPUTATIONAL METHOD [PDF]

, 2013
Concerted interactions between proteins in cells form the basis of most biological processes. Biophysicists study protein–protein association by measuring thermodynamic and kinetic properties.
Zhang, Weiyi
core  

Mechanisms 
of
 change 
in 
protein 
architecture [PDF]

, 2011
Proteins are the basic building blocks and functional units in all living organisms. Moreover, differences between species can frequently be explained with differences in their protein complements.

core   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source