Results 91 to 100 of about 29,703 (304)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Compromise in competition between free energy and binding effect of intrinsically disordered protein p53 C-terminal domain

, 2017
The C-terminal domain (CTD) of tumour suppressor p53 is an intrinsically disordered protein which has been shown to be able to bind multiple partner proteins and exercise diverse physiological functions in the cell.
Ren, Ying, Han, Mengzhi, Xu, Ji
core   +1 more source

A dehydrin-dehydrin interaction: the case of SK3 from Opuntia streptacantha

Frontiers in Plant Science, 2014
Dehydrins belongs to a large group of highly hydrophilic proteins known as Late Embryogenesis Abundant (LEA) proteins. It is well know that dehydrins are intrinsically disordered plant proteins that accumulate during the late stages of embryogenesis and ...
Itzell eHernandez, David eMartynowicz, Aida eRodriguez, Maria Beatriz Pérez-Morales, Steffen P Graether, Juan Francisco Jimenez Bremont   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Low Complexity Induces Structure in Protein Regions Predicted as Intrinsically Disordered

Biomolecules, 2022
There is increasing evidence that many intrinsically disordered regions (IDRs) in proteins play key functional roles through interactions with other proteins or nucleic acids. These interactions often exhibit a context-dependent structural behavior.
Gonçalves-Kulik, Mariane, Mier, Pablo, Kastano, Kristina, Cortés, Juan, Bernadó, Pau, Schmid, Friederike, Andrade-Navarro, Miguel   +6 more
openaire   +6 more sources

A blurry view of fuzzy objects: on the roles of low-resolution structural techniques in discovery and early characterization of intrinsically disordered proteins

Frontiers in Biophysics
The discovery of intrinsically disordered proteins (IDPs) (and, therefore, the establishment of the field of protein intrinsic disorder) was initially driven by low-resolution techniques, which overturned the established “lock-and-key” paradigm of ...
Vladimir N. Uversky
doaj   +1 more source

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells

Haematologica, 2019
As high fetal hemoglobin levels ameliorate the underlying pathophysiological defects in sickle cell anemia and beta (β)-thalassemia, understanding the mechanisms that enforce silencing of fetal hemoglobin postnatally offers the promise of effective ...
Xiaofei Yu, Alexander Azzo, Stephanie M. Bilinovich, Xia Li, Mikhail Dozmorov, Ryo Kurita, Yukio Nakamura, David C. Williams, Gordon D. Ginder   +8 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Understanding Intramolecular Crosstalk in an Intrinsically Disordered Protein

, 2019
International audienceThe interaction between NTAIL and XD from the measles virus represents a paradigmatic example of molecular recognition between an intrinsically disordered protein and a folded partner.
Troilo, Francesca, Longhi, Sonia, Bignon C, Gianni, Stefano, Troilo F., Gianni S, Bonetti, Daniela, Bignon, Christophe, Longhi S, Bonetti D   +9 more
core   +1 more source