Results 71 to 80 of about 7,902,914 (332)

Long-Range Entropic Effects on Protein Intrinsically Disordered Regions [PDF]

, 2019
Entropy calculations represent one of the most challenging steps in obtaining the binding free energy in proteins and their complexes, which is a grand challenge in computational biology.
Agnieszka K., Bronowska, Joao Victor de Souza Cunha (6310883), Joao Victor, de Souza Cunha, Agnieszka K. Bronowska (6320289)   +3 more
core   +1 more source

Protein Expansion Is Primarily due to Indels in Intrinsically Disordered Regions [PDF]

Molecular Biology and Evolution, 2013
Proteins evolve not only through point mutations but also by insertion and deletion events, which affect the length of the protein. It is well known that such indel events most frequently occur in surface-exposed loops. However, detailed analysis of indel events in distantly related and fast-evolving proteins is hampered by the difficulty involved in ...
Light S, Sagit R, Sachenkova O, Ekman D, Elofsson A   +4 more
openaire   +4 more sources

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data [PDF]

, 2009
Background: Disordered proteins need to be expressed to carry out specified functions; however, their accumulation in the cell can potentially cause major problems through protein misfolding and aggregation.
Jones, DT, Pentony, MM, Edwards, YJK, David T Jones, Yvonne JK Edwards, Lobley, AE, Anna E Lobley, Melissa M Pentony   +7 more
core   +1 more source

Benchmarking of force fields to characterize the intrinsically disordered R2-FUS-LC region

Scientific Reports, 2023
Intrinsically Disordered Proteins (IDPs) play crucial roles in numerous diseases like Alzheimer's and ALS by forming irreversible amyloid fibrils. The effectiveness of force fields (FFs) developed for globular proteins and their modified versions for ...
M. Chan-Yao-Chong, Justin Chan, H. Kono
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Conformational ensembles of an intrinsically disordered protein consistent with NMR, SAXS and single-molecule FRET

Journal of the American Chemical Society, 2020
Intrinsically disordered proteins (IDPs) have fluctuating heterogeneous conformations, which makes structural characterization challenging. Although challenging, characterizing the conformational ensembles of IDPs is of great interest, since their ...
Gregory-Neal W. Gomes, M. Krzeminski, Ashley Namini, Erik W. Martin, T. Mittag, T. Head-Gordon, J. Forman-Kay, C. Gradinaru   +7 more
semanticscholar   +1 more source

Inferring function using patterns of native disorder in proteins [PDF]

, 2007
Natively unstructured regions are a common feature of eukaryotic proteomes. Between 30% and 60% of proteins are predicted to contain long stretches of disordered residues, and not only have many of these regions been confirmed experimentally, but they ...
Swindells, MB, Jones, DT, Mark B. Swindells, David T. Jones, Lobley, A, Lobley, A., Christine A. Orengo, David T Jones, Mark B Swindells, Swindells, M.B., Orengo, C.A., Christine A Orengo, Jones, D.T., Anna Lobley, Orengo, CA   +14 more
core   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae

Nature Communications
Disordered protein sequences can exhibit different binding modes, ranging from well-ordered folding-upon-binding to highly dynamic fuzzy binding. The primary function of the intrinsically disordered region of the antitoxin HigA2 from Vibrio cholerae is ...
San Hadži, Zala Živič, Matic Kovačič, Uroš Zavrtanik, Sarah Haesaerts, Daniel Charlier, Janez Plavec, Alexander N. Volkov, Jurij Lah, Remy Loris   +9 more
doaj   +1 more source

SARS-CoV-2 nucleocapsid protein undergoes liquid–liquid phase separation into stress granules through its N-terminal intrinsically disordered region

Cell Discovery, 2021
Dear Editor, The novel coronavirus disease 19 (COVID-19) broke out in late 2019 and has spread worldwide since then, posing a great threat to the world economy and public health. As of December 1, 2020, more than 62.8 million patients have been diagnosed
Jia Wang, Chengrui Shi, Qun Xu, Hang Yin
semanticscholar   +1 more source