Results 61 to 70 of about 7,902,914 (332)

Contributions of the N‐terminal intrinsically disordered region of the severe acute respiratory syndrome coronavirus 2 nucleocapsid protein to RNA‐induced phase separation

Protein Science, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) nucleocapsid protein is an essential structural component of mature virions, encapsulating the genomic RNA and modulating RNA transcription and replication.
M. Zachrdla, A. Savastano, Alain Ibáñez de Opakua, Maria-Sol Cima-Omori, M. Zweckstetter   +4 more
semanticscholar   +1 more source

DARUMA: a gateway to fast and easy prediction of intrinsically disordered regions [PDF]

PeerJ Computer Science
Background Intrinsically disordered proteins (IDPs) are proteins that contain intrinsically disordered regions (IDRs), which lack stable three-dimensional structures under physiological conditions.
Itsuki Shimizu, Takuya Ida, Yuhei Ozawa, Satoshi Fukuchi, Hiroto Anbo   +4 more
doaj   +2 more sources

Intrinsically disordered chromatin protein NUPR1 binds to the enzyme PADI4.

Journal of Molecular Biology, 2023
The nuclear protein 1 (NUPR1) is an intrinsically disordered protein involved in stress-mediated cellular conditions. Its paralogue nuclear protein 1-like (NUPR1L) is p53-regulated, and its expression down-regulates that of the NUPR1 gene.
Salomé Araujo-Abad, J. Neira, B. Rizzuti, P. García-Morales, C. de Juan Romero, P. Santofimia-Castaño, J. Iovanna   +6 more
semanticscholar   +1 more source

The molecular basis for cellular function of intrinsically disordered protein regions

Nature Reviews Molecular Cell Biology, 2023
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These regions are structurally heterogeneous, ubiquitous and found across all kingdoms of life. Despite the absence of a defined 3D structure, disordered regions are essential for cellular processes ranging from ...
Alex S. Holehouse, Birthe B. Kragelund
openaire   +4 more sources

Intrinsically disordered region-mediated condensation of IFN-inducible SCOTIN/SHISA-5 inhibits ER-to-Golgi vesicle transport.

Developmental Cell, 2023
Newly synthesized proteins in the endoplasmic reticulum (ER) are sorted by coat protein complex II (COPII) at the ER exit site en route to the Golgi. Under cellular stresses, COPII proteins become targets of regulation to control the transport.
Nari Kim, Tae-Hyeon Kim, Chaelim Kim, Jee-Eun Lee, Myeong-Gyun Kang, Sanghee Shin, Minkyo Jung, Jong-Seo Kim, Ji-Young Mun, Hyun-Woo Rhee, Seung-Yeol Park, Yongdae Shin, Joo-Yeon Yoo   +12 more
semanticscholar   +1 more source

Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle [PDF]

, 2007
The potent immunomodulatory, anti-inflammatory and procoagulant properties of the protein no. 4 secreted from the rat seminal vesicle epithelium (SV-IV) have been previously found to be modulated by a supramolecular monomer-trimer ...
Silvia Vilasi, Raffaele Ragone, Silvia Vilasi, AND RAGONE R., VILASI, SILVIA   +4 more
core   +1 more source

OPAL: prediction of MoRF regions in intrinsically disordered protein sequences [PDF]

Bioinformatics, 2018
AbstractMotivationIntrinsically disordered proteins lack stable 3-dimensional structure and play a crucial role in performing various biological functions. Key to their biological function are the molecular recognition features (MoRFs) located within long disordered regions. Computationally identifying these MoRFs from disordered protein sequences is a
Ronesh Sharma, Gaurav Raicar, Tatsuhiko Tsunoda, Ashwini Patil, Alok Sharma   +4 more
openaire   +4 more sources

Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein [PDF]

, 2012
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral ...
Krause Kurt L., Luckner, Sylvia R., Krause, Kurt L., Luckner Sylvia R., Lambden, Paul R., Sylvia R Luckner, Kurt L Krause, Clarke, Ian N., Paul R Lambden, Baker, Estelle S., Ian N Clarke, Baker Estelle S., Estelle S Baker, Ward Vernon K., Lambden Paul R., Ward, Vernon K., Clarke Ian N., Vernon K Ward   +17 more
core   +1 more source

Rapid Evolution of Virus Sequences in Intrinsically Disordered Protein Regions [PDF]

PLoS Pathogens, 2014
Nodamura Virus (NoV) is a nodavirus originally isolated from insects that can replicate in a wide variety of hosts, including mammals. Because of their simplicity and ability to replicate in many diverse hosts, NoV, and the Nodaviridae in general, provide a unique window into the evolution of viruses and host-virus interactions. Here we show that the C-
Gitlin, Leonid, Hagai, Tzachi, LaBarbera, Anthony, Solovey, Mark, Andino, Raul   +4 more
openaire   +5 more sources

D2P2: database of disordered protein predictions [PDF]

, 2013
We present the Database of Disordered Protein Prediction (D2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein ...
Oates, Matt E., Ishida, Takashi, Dosztányi, Zsuzsanna, Romero, Pedro   +3 more
core   +1 more source