Results 141 to 150 of about 4,409,964 (303)

Understanding Intramolecular Crosstalk in an Intrinsically Disordered Protein

, 2019
International audienceThe interaction between NTAIL and XD from the measles virus represents a paradigmatic example of molecular recognition between an intrinsically disordered protein and a folded partner.
Troilo, Francesca, Longhi, Sonia, Bignon C, Gianni, Stefano, Troilo F., Gianni S, Bonetti, Daniela, Bignon, Christophe, Longhi S, Bonetti D, Bonetti D., Longhi S., Gianni S., Bignon C.   +13 more
core   +1 more source

High‐Entropy Alloy Interlayers Toward Advanced Joining for High‐Performance Structural Applications: Current Progress and Emerging Challenges

Advanced Engineering Materials, EarlyView.
HEA interlayers offer a versatile route for joining high‐performance structural materials. Their compositional and structural design regulates interfacial reactions, suppresses brittle IMCs, and improves metallurgical bonding. Sandwich interlayers further integrate defect healing with precipitation strengthening, enabling improved strength–ductility ...
Lin Yuan, Jiafen Song, Jinglong Li, Jiangtao Xiong, Tao Yang   +4 more
wiley   +1 more source

Intrinsically Disordered Proteins May Select Partners by Fold [PDF]

, 2013
Intrinsically disordered proteins lack a rigid structure due to their simple amino acid sequence. Because of their multiple roles, disordered proteins often account for a majority of proteins known to be associated with various diseases.
Gonzalez, Kim 1988-
core  

Elastic–Plastic Modeling and Experimental Characterization of Granular Jamming Actuators

Advanced Engineering Materials, EarlyView.
Granular jamming enables rapid switching between soft and rigid mechanical states. Here, a reduced‐order elastic‐perfectly‐plastic beam framework captures pressure‐dependent loading, unloading, residual deformation, and hysteresis in jammed beams, while matching three‐point bending experiments across materials and geometries. The framework links design
Saheli Patel, Prashant K. Purohit, Jordan R. Raney   +2 more
wiley   +1 more source

Design principles of transcription factors with intrinsically disordered regions

eLife
Transcription factors (TFs) are proteins crucial for regulating gene expression. Effective regulation requires the TFs to rapidly bind to their correct target, enabling the cell to respond efficiently to stimuli such as nutrient availability or the presence of toxins.
Wencheng Ji, Ori Hachmo, Naama Barkai, Ariel Amir   +3 more
openaire   +4 more sources

3.9 Intrinsically Disordered Proteins

, 2012
This chapter introduces intrinsically disordered proteins, which do not have rigid three-dimensional (3-D) structures under physiological conditions, but which nevertheless carry out numerous biological functions.
A.K. Dunker, V.N. Uversky, Uversky, Vladimir N., Dunker, A. Keith   +3 more
core   +1 more source

Microstructure‑Dependent Phase Transformations Under High‑Pressure Laser Heating in Additively Manufactured AlCrFe2Ni2

Advanced Engineering Materials, EarlyView.
Additively manufactured AlCrFe2Ni2 with contrasting BCC/B2‐dominant and lamellar FCC + BCC/B2 microstructures exhibits the same pressure‐induced BCC/B2 → HCP transformation. Under laser heating at high pressure, HCP is destabilized, and a cubic BCC/B2 + FCC assemblage is recovered, while the lower‐scan‐speed microstructure transforms at a lower ...
Raimundas Sereika, Hunter Kantelis, Yogesh K. Vohra, Shengbiao Zhang, Wuxian Yang, Wen Chen   +5 more
wiley   +1 more source

A Regulatory Element in the Intrinsically Disordered C-Terminal Region of LMTK3 Modulates Its Kinase Domain Interactions and Breast Cancer Phenotypes

Cells
Lemur tail kinase 3 (LMTK3) is an oncogenic Ser/Thr kinase implicated in breast cancer (BC) progression, therapy resistance, and poor clinical outcomes, yet the molecular mechanisms governing its regulation remain poorly understood, particularly the role
Andrea Lauer Betrán, Alessandro Agnarelli, Mark Samuels, Viviana Vella, Reza Shirazi Nia, Daniel De Vega, Niloufar Poudine, Daniela Carter-Lopez, Angeliki Ditsiou, Murat Eravci, Chrisostomos Prodromou, Erika J. Mancini, Georgios Giamas   +12 more
doaj   +1 more source

Impact of Hydrogen Incorporation on Electronic and Magnetic Structure of X2CrNi18‐9 Stainless Steel

Advanced Engineering Materials, EarlyView.
Hydrogen uptake in austenitic stainless steel alters both its electronic and magnetic structure. Seebeck measurements reveal hydrogen‐induced shifts in the electronic density of states, while neutron scattering uncovers nanoscale inhomogeneities that grow upon hydrogen incorporation, with the most pronounced effect observed in the PBF as‐built state ...
Torben Tappe, Louis Becker, Gaurav Kanu, Thomas F. Headen, Dirk Honecker, Gabi Schierning, Santiago Benito, Sebastian Weber, Klara Lünser, Sabrina Disch   +9 more
wiley   +1 more source

Intrinsically disordered regions-based aquareceptors

In the emerging field of gasocrinology, it is important not only to identify all the gasoreceptors involved in gasocrine signaling, as well as those that exhibit duality or multimodality in sensing other molecules or factors.1,2 Earlier, I proposed that hemoglobin acts an oxygen gasoreceptor in a proto- or split-component signal transduction system ...
openaire   +2 more sources