Results 161 to 170 of about 32,541 (302)

Intrinsically Disordered Landscapes for Human CD4 Receptor Peptide.

, 2019
Because of their inherent structural plasticity, intrinsically disordered proteins (IDPs) are generally difficult to characterize, both experimentally and via simulations.

core   +1 more source

Molecular driving force of a small molecule-induced protein disorder-order transition

Communications Chemistry
The selectivity and affinity of numerous protein–protein interactions depends upon the folding of intrinsically disordered regions (IDRs) that accompanies complexation.
Cesar Mendoza-Martinez, Arun A. Gupta, Salomé Llabrés, Paul N. Barlow, Julien Michel   +4 more
doaj   +1 more source

Unraveling MXene Oxidation Mechanisms Under Realistic Gas Environments by In Situ Gas‐Cell TEM

Advanced Functional Materials, EarlyView.
Real‐time visualization of MXene degradation reveals a fundamental oxidation mechanism under oxygen and moisture environments. Using in situ gas‐cell electron microscopy, this study demonstrates that oxygen degradation drives a thermodynamically controlled high‐temperature transformation into mixed rutile/anatase phases.
Yongfa Cheng, Kunmo Koo, Zizhen Cai, Paty Meza, Yu Wen, Byungseok Seo, Yukun Liu, Xiaobing Hu, Vinayak P. Dravid   +8 more
wiley   +1 more source

The Hydrophilic Domain of HSulf Endosulfatases: An Intrinsically Disordered Region Governing Enzyme Functions and Therapeutic Potential

International audienceAbstract Human extracellular endosulfatases HSulf-1 and HSulf-2 catalyze the selective 6-O-desulfation of heparan sulfate (HS), critically shaping the sulfation code that governs glycosaminoglycan (GAG)-mediated signaling.
Uchimura, K, Tao, J, Demongin, Clément, Basdevant, N, Daniel, Régis, El Omrani, N   +5 more
core   +1 more source

Unusual Biophysics of Intrinsically Disordered Proteins

, 2013
Research of a past decade and a half leaves no doubt that complete understanding of protein functionality requires close consideration of the fact that many functional proteins do not have well-folded structures.
Uversky, Vladimir N.
core   +1 more source

A Skin‐Like Strain Sensor for Real‐Time Human Motion Detection

Advanced Functional Materials, EarlyView.
A skin‐like strain sensor with exceptional flexibility and breathability enables real‐time human motion detection. It offers continuous ECG monitoring and gesture recognition, ensuring high durability and comfort. This innovative design is ideal for wearable applications, combining reliable performance with seamless integration into dynamic ...
Shiqi Song, Zhe Li, Jingya Guo, Shuo Shi, Jian Fang, Xungai Wang   +5 more
wiley   +1 more source

Discovery of a Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC

, 2020
MYC is a major oncogenic transcriptional driver of most human cancers. Yet, MYC has remained intractable to direct targeting because much of MYC is intrinsically disordered and there are no known obvious pockets within MYC that can be pharmacologically ...
Co, Jennifer, Liu, Gang, Nomura, Daniel K., Schirle, Markus, Tallarico, John, McKenna, Jeffrey, Majewski, Felix C., Boike, Lydia, Jones, Michael, Cioffi, Alexander, Henning, Nathaniel J.   +10 more
core  

Electro‐Steric Ion Confinement in Polyelectrolyte Networks for Robust Nonvolatile Artificial Synapse

Advanced Functional Materials, EarlyView.
Polyelectrolyte stoichiometry governs ion transport and retention in electrolyte‐gated synaptic transistors. A PSS‐rich network creates electro‐steric ion confinement that suppresses ion back‐diffusion and stabilizes channel doping, enabling robust nonvolatile synaptic memory, linear weight updates, and low‐energy operation.
Donghwa Lee, Jinbo Kim, Myeongjin An, Jisoo Park, Junho Sung, Eunsung Hwang, Suhwan Seok, Seong‐Min Bak, Jeonghun Kim, Eunho Lee   +9 more
wiley   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

A Molecular Shielding Strategy to Develop Low Protein Binding, Renal Clearable Pan‐Cancer Near‐Infrared Probes

Advanced Functional Materials, EarlyView.
A molecular shielding strategy to convert “protein‐sticky” and “non‐tumor specific” clinical ICG dye, into a “low protein binding” and “tumor‐targeting” dye with prolonged blood circulation and renal clearance is described. These shielded ICGs demonstrate strong tumor accumulation and optimal tissue clearance, resulting in high tumor‐to‐background ...
Li Xiang, Kailin Mooney, Mingchong Dai, Morgan R. Stewart, Samantha Holland, Michael I. Henderson, Samuel Drennan, Ramon F. Barajas Jr., Jared M. Fischer, Adem Yildirim   +9 more
wiley   +1 more source