Results 261 to 270 of about 4,409,964 (303)

Exploring the Role of Globular Domain Locations on an Intrinsically Disordered Region of p53: A Molecular Dynamics Investigation. [PDF]

J Chem Theory Comput
Bakker MJ, Sørensen HV, Skepö M.
europepmc   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12. [PDF]

Nat Commun
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G.   +16 more
europepmc   +1 more source

Interaction Between PHF8 and a Segment of KDM2A, Which Is Controlled by the Phosphorylation Status at a Specific Serine in an Intrinsically Disordered Region of KDM2A, Regulates rRNA Transcription and Cell Proliferation in a Breast Cancer Cell Line. [PDF]

Biomolecules
Okamoto K, Mihara Y, Ogasawara S, Murakami T, Ohmori S, Mori T, Umata T, Kawasaki Y, Hirano K, Yano H, Tsuneoka M.   +10 more
europepmc   +1 more source

Invariant BECN1 CXXC motifs bind Zn²⁺ and regulate structure and function of the BECN1 intrinsically disordered region. [PDF]

Autophagy
Mukhopadhyay S, Subedi S, Hopkins JB, Ugrinov A, Chakravarthy S, Colbert CL, Sinha SC.   +6 more
europepmc   +1 more source

The origin recognition complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man. [PDF]

Nucleic Acids Res
Adiji OA, McConnell BS, Parker MW.
europepmc   +1 more source

Intrinsically Disordered Proteins and Proteins With Intrinsically Disordered Regions in Neurodegenerative Diseases

Biophysical Reviews, 2022
Many different intrinsically disordered proteins and proteins with intrinsically disordered regions are associated with neurodegenerative diseases. These types of proteins including amyloid-β, tau, α-synuclein, CHCHD2, CHCHD10, and G-protein coupled receptors are increasingly becoming evaluated as potential drug targets in the pharmaceutical-based ...
Orkide Coşkuner-Weber, Vladimir Uversky
exaly   +5 more sources

Classification of Intrinsically Disordered Regions and Proteins

Chemical Reviews, 2014
1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from a variety of organisms.1,2 While this may reflect the diversity in sequence space, and possibly also in function space,3 a large proportion of the sequences ...
Benjamin Lang, Robin van der Lee, Peter Tompa   +2 more
exaly   +6 more sources

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Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

Annual Review of Biochemistry, 2014
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet they exhibit biological activities. Their mobile flexibility and structural instability are encoded by their amino acid sequences. They recognize proteins, nucleic acids, and other types of partners; they accelerate interactions and chemical reactions between ...
Christopher J, Oldfield, A Keith, Dunker
openaire   +2 more sources

Intrinsically Disordered Proteins/Regions and Insight Into Their Biomolecular Interactions

Biophysical Chemistry, 2022
Proteins may vary from being rigid to having flexible regions to being completely disordered, either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered regions (IDRs). IDPs/IDRs can form complexes otherwise impossible, such as wrapping around the binding partner, hence providing the plasticity needed for achieving ...
Pinak Chakrabarti, Devlina Chakravarty
exaly   +3 more sources