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Engineering intrinsically disordered regions for guiding genome navigation
Molecular CellIntrinsically disordered regions (IDRs) navigate transcription factors (TFs) to their binding sites in genomes, raising the question of how IDR sequences can encode for specific genome recognition. To define the principles of IDR-directed binding, we designed de novo IDRs and tested their activity in directing selective binding across the budding yeast
Jing, Liu +4 more
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Computational Methods to Predict Intrinsically Disordered Regions and Functional Regions in Them
2023Intrinsically disordered regions (IDRs) are protein regions that do not adopt fixed tertiary structures. Since these regions lack ordered three-dimensional structures, they should be excluded from the target portions of homology modeling. IDRs can be predicted from the amino acid sequences, because their amino acid compositions are different from that ...
Hiroto, Anbo +2 more
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Decoding intrinsically disordered regions in chromatin dysfunction and cancer
Journal of Cell ScienceABSTRACT Intrinsically disordered regions (IDRs) are pervasive in chromatin regulatory proteins, where their dynamic, multivalent interactions organize nuclear biochemistry, in some cases through biomolecular condensation. Because ∼20% of cancer-driver mutations map to disordered regions – for which traditional structure–function ...
Audrey W. Hong +2 more
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Prediction of Intrinsically Disordered Regions That Bind RNA with DisoRDPbind
A common cellular function of intrinsically disordered regions (IDRs) is molecular binding, which covers interactions with various partner molecules, including proteins, peptides, nucleic acids, lipids, and small molecules. While there are many computational predictors of binding IDRs, relatively few target IDRs that bind RNAs.Zhenling, Peng, Lukasz, Kurgan
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The Hsp90 Molecular Chaperone Governs Client Proteins by Targeting Intrinsically Disordered Regions
Molecular Cell, 2023Brian C. Freeman
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Intrinsically Disordered Regions Direct Transcription Factor in Vivo Binding Specificity
Molecular Cell, 2020Miri Carmi +2 more
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Intrinsically Disordered Proteins: An Overview
International Journal of Molecular Sciences, 2022Hampapathalu A Nagarajaram +1 more
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Intrinsically Disordered Regions Are Poised to Act as Sensors of Cellular Chemistry
Trends in Biochemical Sciences, 2023Garrett M Ginell +2 more
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Intrinsically Disordered Proteins in Cellular Signalling and Regulation
Nature Reviews Molecular Cell Biology, 2015Helen Jane Dyson, Peter Wright
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