Results 91 to 100 of about 4,746 (287)
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Features extracted from sequences of intrinsically disordered regions.
, 2014 Features extracted from sequences of intrinsically disordered regions.
Kenta Nakai (408) +6 more
core +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Proteins of generalist and specialist pathogens differ in their amino acid composition
Life Science Alliance, 2018 Primitive amino acids and disorder content in secreted proteins are distinctively enriched in generalist compared with host-specific pathogens. Pathogens differ in their host specificities, with species infecting a unique host (specialist pathogens) and ...
Luz P Blanco +3 more
doaj +1 more source
, 2019 Intrinsically disordered proteins (IDPs) are molecules without a fixed tertiary structure, exerting crucial roles in cellular signalling, growth and molecular recognition events. Due to their high plasticity, IDPs are very challenging in experimental and
Agnieszka K., Bronowska +2 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Buried and accessible surface area control intrinsic protein flexibility [PDF]
, 2013 Proteins experience a wide variety of conformational dynamics that can be crucial for facilitating their diverse functions. How is the intrinsic flexibility required for these motions encoded in their three-dimensional structures?
Marsh, Joseph A; id_orcid
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu +10 more
wiley +1 more source
D2P2: database of disordered protein predictions
, 2013 We present the Database of Disordered Protein Prediction (D2P2), available at http://d2p2.pro (including website source code). A battery of disorder predictors and their variants, VL-XT, VSL2b, PrDOS, PV2, Espritz and IUPred, were run on all protein ...
Oates, Matt E. +3 more
core
Intrinsically Disordered Proteins & Regions in Viruses and Possibly Pharmaceuticals
, 2021 This review examines the significance of intrinsically disordered proteins (IDPs) and regions to viruses and their prospects as vaccine components. Using a content analysis of scientific articles, reviews, interviews, industry updates and magazines, it ...
Cerda, Nicholas Alexander
core +1 more source