Results 81 to 90 of about 4,746 (287)

Mechanisms 
of
 change 
in 
protein 
architecture

, 2011
Proteins are the basic building blocks and functional units in all living organisms. Moreover, differences between species can frequently be explained with differences in their protein complements.

core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Intrinsic structural disorder in cytoskeletal proteins.

, 2013
Cytoskeleton, the internal scaffold of the cell, displays an exceptional combination of stability and dynamics. It is composed of three major filamentous networks, microfilaments (actin filaments), intermediate filaments (neurofilaments), and ...
Szabó, Beáta, Guharoy, Majnak, Martos, Sara Contreras, Tompa, Péter   +3 more
core   +1 more source

Human long intrinsically disordered protein regions are frequent targets of positive selection [PDF]

, 2018
Intrinsically disordered regions occur frequently in proteins and are characterized by a lack of a well-defined three-dimensional structure. Although these regions do not show a higher-order of structural organization, they are known to be functionally ...
Mathias Bockwoldt, Bockwoldt, M., Cooney, Christopher, Afanasyeva, A., Christopher R. Cooney, Bockwoldt, Mathias, Cooney, Christopher R., Heiland, Ines, Gossmann, Toni Ingolf, Toni I. Gossmann, Heiland, I., Gossmann, T., Afanasyeva, Arina, Ines Heiland, Cooney, C., Arina Afanasyeva, Goßmann, Toni ; https://orcid.org/   +16 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

The disordered boundary of the cell: emerging properties of membrane-bound intrinsically disordered proteins

Biomolecular Concepts, 2019
We define the disordered boundary of the cell (DBC) as the system formed by membrane tethered intrinsically disordered protein regions, dynamically coupled to the underlying membrane.
Mohammad Irrem-Laareb, Mateos Borja, Pons Miquel   +2 more
doaj   +1 more source

Intrinsically disordered regions (IDRs) that are intolerant to mutations and their categories.

, 2022
Intrinsically disordered regions (IDRs) that are intolerant to mutations and their categories.
Arthur J. Campbell (2167885), A. Keith Dunker (268445), M. Sohel Rahman (12056885), Zaara T. Rifat (12231724), Ruchi Lohia (5955317), Sumaiya Iqbal (820489), Shehab S. Ahmed (12231721)   +6 more
core   +1 more source

Backbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation [PDF]

, 2022
Benedikt Goretzki, Frederike Tebbe, Sarah-Ana Mitrovic, Ute A. Hellmich   +3 more
openalex   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

vmindel/MinBro2023: Intrinsically disordered regions of Msn2 transcription factor encode multiple functions using interwoven sequence grammars

, 2023
Intrinsically disordered regions of transcription factor encode multiple functions using interwoven sequence ...
Vova Mindel
core   +1 more source