Results 21 to 30 of about 2,551 (127)

Intrinsically photosensitive retinal ganglion cells in glaucoma

Frontiers in Cellular Neuroscience, 2022
Glaucoma is a group of eye diseases afflicting more than 70 million people worldwide. It is characterized by damage to retinal ganglion cells (RGCs) that ultimately leads to the death of the cells and vision loss.
Jingyi Gao, Ignacio Provencio, Ignacio Provencio, Ignacio Provencio, Xiaorong Liu, Xiaorong Liu, Xiaorong Liu, Xiaorong Liu   +7 more
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Blurring the Boundaries of Vision: Novel Functions of Intrinsically Photosensitive Retinal Ganglion Cells

Journal of Experimental Neuroscience, 2013
Mammalian vision consists of the classic image-forming pathway involving rod and cone photoreceptors interacting through a neural network within the retina before sending signals to the brain, and a non image-forming pathway that uses a photosensitive ...
Anna Matynia
doaj   +1 more source

Intrinsically Photosensitive Retinal Ganglion Cells of the Human Retina

Frontiers in Neurology, 2021
Light profoundly affects our mental and physical health. In particular, light, when not delivered at the appropriate time, may have detrimental effects.
Ludovic S. Mure, Ludovic S. Mure
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M1-Type, but Not M4-Type, Melanopsin Ganglion Cells Are Physiologically Tuned to the Central Circadian Clock

Frontiers in Neuroscience, 2021
Proper circadian photoentrainment is crucial for the survival of many organisms. In mammals, intrinsically photosensitive retinal ganglion cells (ipRGCs) can use the photopigment melanopsin to sense light independently from rod and cone photoreceptors ...
Adam R. Stinchcombe, Caiping Hu, Olivia J. Walch, Samuel D. Faught, Kwoon Y. Wong, Kwoon Y. Wong, Daniel B. Forger, Daniel B. Forger, Daniel B. Forger   +8 more
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Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy

Cell Reports, 2023
Summary: Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes. We compared retinal ganglion cell (RGC) responses between chronic glaucomatous conditions and the acute injury model. Among major RGC subclasses, αRGCs and
Mengya Zhao, Kenichi Toma, Benyam Kinde, Liang Li, Amit K. Patel, Kong-Yan Wu, Matthew R. Lum, Chengxi Tan, Jody E. Hooper, Arnold R. Kriegstein, Anna La Torre, Yaping Joyce Liao, Derek S. Welsbie, Yang Hu, Ying Han, Xin Duan   +15 more
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Blue light activates pulvinar nuclei in longstanding idiopathic photophobia: A case report

NeuroImage: Clinical, 2019
Numerous pathologies can contribute to photophobia. When considering light transduction alone, photophobia may be triggered through melanopsin pathways (non-image forming), rod and cone pathways (image-forming), or some combination of the two.
Athanasios Panorgias, Danielle Lee, Katie E. Silva, David Borsook, Eric A. Moulton   +4 more
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Immediate responses to ambient light in vivo reveal distinct subpopulations of suprachiasmatic VIP neurons

iScience, 2023
Summary: The circadian rhythm pacemaker, the suprachiasmatic nucleus (SCN), mediates light entrainment via vasoactive intestinal peptide (VIP) neurons (SCNVIP).
Anat Kahan, Karan Mahe, Sayan Dutta, Pegah Kassraian, Alexander Wang, Viviana Gradinaru   +5 more
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Axonal synapses utilize multiple synaptic ribbons in the mammalian retina. [PDF]

PLoS ONE, 2012
In the mammalian retina, bipolar cells and ganglion cells which stratify in sublamina a of the inner plexiform layer (IPL) show OFF responses to light stimuli while those that stratify in sublamina b show ON responses.
Hong-Lim Kim, Ji Hyun Jeon, Tae-Hyung Koo, U-Young Lee, Eojin Jeong, Myung-Hoon Chun, Jung-Il Moon, Stephen C Massey, In-Beom Kim   +8 more
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Melanopsin Driven Light Responses Across a Large Fraction of Retinal Ganglion Cells in a Dystrophic Retina

Frontiers in Neuroscience, 2020
Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin and project to central targets, allowing them to contribute to both image-forming and non-image forming vision.
Cyril G. Eleftheriou, Phillip Wright, Annette E. Allen, Daniel Elijah, Franck P. Martial, Robert J. Lucas   +5 more
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Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells

BMC Genomics, 2021
Background Emerging evidence indicates that long noncoding RNAs (lncRNAs) are important regulators of various biological processes, and their expression can be altered following certain pathological conditions, including central nervous system injury ...
Ana C. Ayupe, Felipe Beckedorff, Konstantin Levay, Benito Yon, Yadira Salgueiro, Ramin Shiekhattar, Kevin K. Park   +6 more
doaj   +1 more source