Alternative processing of bovine growth hormone mRNA: nonsplicing of the final intron predicts a high molecular weight variant of bovine growth hormone. [PDF]
, 1987 R K Hampson, Fritz Rottman
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Advanced Science, EarlyView.Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin +15 more
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Identification of possible differences in coding and non-coding fragments of DNA sequences by using the method of the Recurrence Quantification Analysis [PDF]
arXiv, 2009 Starting with the results of Li et al. in 1992 there is valuable interest in finding long range correlations in dna sequences since it raises questions about the role of introns and intron-containing genes. In the present paper we studied two sequences.
arxiv
A processed pseudogene in an intron of the HLA-DPβ1 chain gene is a member of the ribosomal protein L32 gene family [PDF]
, 1985 John A. T. Young, John Trowsdale
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Advanced Science, EarlyView.A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma +13 more
wiley +1 more source
Transcript length mediates developmental timing of gene expression across Drosophila [PDF]
arXiv, 2013 The time required to transcribe genes with long primary transcripts may limit their ability to be expressed in cells with short mitotic cycles, a phenomenon termed intron delay. As such short cycles are a hallmark of the earliest stages of insect development, we used Drosophila developmental timecourse expression data to test whether intron delay ...
arxiv
Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron. [PDF]
, 1986 Martha L. Peterson, Robert P. Perry
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Advanced Science, EarlyView.Pancreatic cancer is a highly aggressive malignancy with limited treatment options. CLK4 regulates alternative splicing, contributing to cancer progression. This study establishes a computational model to identify CLK4 inhibitors, leading to compound 150441 (IC50: 21.4 nm).
Chun‐Lin Yang +13 more
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Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason +2 more
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Identification of a phenotype-specific enhancer in the first intron of the rat collagen II gene. [PDF]
, 1987 Walter E. Horton +4 more
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