Results 141 to 150 of about 482,093 (336)

Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention.

Genes & Development, 2012
Differentiated cells acquire unique structural and functional traits through coordinated expression of lineage-specific genes. An extensive battery of genes encoding components of the synaptic transmission machinery and specialized cytoskeletal proteins ...
Karen Yap, Z. Q. Lim, P. Khandelia, Brad A. Friedman, E. Makeyev   +4 more
semanticscholar   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Functional Analysis of the ZAG2 Promoter from Maize in Transgenic Tobaccos

Journal of Integrative Agriculture, 2012
: The function of the 3 040 bp sequence at the upstream translation starting site (ATG) of the ZAG2 gene, isolated from the maize genome, was studied.
Min-hui LU, Guo-ying WANG, Zheng MENG, Jian-hua WANG   +3 more
doaj  

Contribution of Mobile Group II Introns to Sinorhizobium meliloti Genome Evolution

Frontiers in Microbiology, 2018
Mobile group II introns are ribozymes and retroelements that probably originate from bacteria. Sinorhizobium meliloti, the nitrogen-fixing endosymbiont of legumes of genus Medicago, harbors a large number of these retroelements.
Nicolás Toro, Francisco Martínez-Abarca, María D. Molina-Sánchez, Fernando M. García-Rodríguez, Rafael Nisa-Martínez   +4 more
doaj   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Stability domains of actin genes and genomic evolution

, 2007
In eukaryotic genes the protein coding sequence is split into several fragments, the exons, separated by non-coding DNA stretches, the introns. Prokaryotes do not have introns in their genome.
A. Dkhissi, B. Alberts, D. Poland, E. Carlon, J. W. Bizzaro, K. A. Marx, M. Lejard Malki, N. J. Dibb, R. Blossey, S. W. Roy   +9 more
core   +1 more source

Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement. [PDF]

, 1985
Michael Dush, James M. Sikela, SA Khan, Jay A. Tischfield, P J Stambrook   +4 more
openalex   +1 more source

The effects of a stimulating intron on the expression of heterologous genes in Arabidopsis thaliana.

Plant Biotechnology Journal, 2013
Introns are often added to transgenes to increase expression, although the mechanism through which introns stimulate gene expression in plants and other eukaryotes remains mysterious.
S. Emami, D. Arumainayagam, I. Korf, A. Rose   +3 more
semanticscholar   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source