Results 51 to 60 of about 317,196 (344)
Nucleic Acids Research, 1987 The sequence information for the splicing process of introns is found in the consensus sequences at the two splice sites. For long introns, of 300 or more nucleotides, the middle regions may provide additional specificity for splicing which can be investigated by defining an adequate quantitative parameter.
Christian J. Michel, Didier Arquès
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Hayati Journal of Biosciences, 2013 Unambiguous insertion-deletion events were previously identified in trnL intron of 110 species of subfamily Dipterocarpoideae (Dipterocarpaceae). These indels are associated with the formation of four stem loop structures and featuring characteristic for
KUSUMADEWI SRI YULITA
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A Review for the Special Issue on Paramecium as a Modern Model Organism
Microorganisms, 2023 This review provides background and perspective for the articles contributing to the Special Issue of MDPI Micro-organisms on Paramecium as a Modern Model Organism.
Judith Van Houten
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Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS
Nature Communications, 2018 Mutations causing amyotrophic lateral sclerosis (ALS) strongly implicate ubiquitously expressed regulators of RNA processing. To understand the molecular impact of ALS-causing mutations on neuronal development and disease, we analysed transcriptomes ...
Raphaëlle Luisier +12 more
semanticscholar +1 more source
Intron definition in splicing of small Drosophila introns. [PDF]
Molecular and Cellular Biology, 1994 Approximately half of the introns in Drosophila melanogaster are too small to function in a vertebrate and often lack the pyrimidine tract associated with vertebrate 3' splice sites. Here, we report the splicing and spliceosome assembly properties of two such introns: one with a pyrimidine-poor 3' splice site and one with a pyrimidine-rich 3' splice ...
M Talerico, Susan M. Berget
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The Globin Gene Family in Arthropods: Evolution and Functional Diversity
Frontiers in Genetics, 2020 Globins are small heme-proteins that reversibly bind oxygen. Their most prominent roles in vertebrates are the transport and storage of O2 for oxidative energy metabolism, but recent research has suggested alternative, non-respiratory globin functions ...
Andreas Prothmann +8 more
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An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
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IRFinder: assessing the impact of intron retention on mammalian gene expression
Genome Biology, 2017 Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the final mRNA. We have developed a program and database called IRFinder to accurately detect IR from mRNA sequencing data.
Robert Middleton +10 more
semanticscholar +1 more source
mAbs, 2023 Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence ...
Emma Kelsall +5 more
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Expression of the C-allele of intronic rs8192675 in SLC2A2 is associated with improved glucose response to metformin [PDF]
Genetics and Molecular BiologyGlucose is a critical nutrient for energy metabolism. The SLC2A2 gene is essential for glucose sensing and homeostasis, as it encodes the facilitated glucose transporter GLUT2. During diabetes treatment, the C-allele of rs8192675 in SLC2A2 has been found
Wanjun Wang +4 more
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