Results 121 to 130 of about 292,600 (397)
FEBS Open Bio, EarlyView.The C. elegans tetraspanin‐7 (tsp‐7) is a homologue of human CD63, which is a negative regulator of autophagy. The C. elegans strain, tm5761, has a dysfunctional (knockout) tsp‐7 gene. When compared to the wild‐type strain, the tm5761 strain shows increased: life‐ and health‐span; thermotolerance, and stress‐induced locomotion.
Brogan Jones +2 more
wiley +1 more source
Evolutionary dynamics of U12-type spliceosomal introns
BMC Evolutionary Biology, 2010 Background Many multicellular eukaryotes have two types of spliceosomes for the removal of introns from messenger RNA precursors. The major (U2) spliceosome processes the vast majority of introns, referred to as U2-type introns, while the minor (U12 ...
Mount Stephen M +3 more
doaj +1 more source
Using profiles based on hydropathy properties to define essential regions for splicing [PDF]
International Journal of Biological Sciences (2009) 10 p, 2009 We define new profiles based on hydropathy properties and point out specific profiles for regions surrounding splice sites. We built a set T of flanking regions of genes with 1-3 introns from 21st and 22nd chromosomes. These genes contained 313 introns and 385 exons and were extracted from GenBank. They were used in order to define hydropathy profiles.
arxiv
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Evolution of the Exon-Intron Structure in Ciliate Genomes. [PDF]
PLoS ONE, 2016 A typical eukaryotic gene is comprised of alternating stretches of regions, exons and introns, retained in and spliced out a mature mRNA, respectively.
Vladyslav S Bondarenko +1 more
doaj +1 more source
Group II introns: mobile ribozymes that invade DNA.
Cold Spring Harbor Perspectives in Biology, 2011 Group II introns are mobile ribozymes that self-splice from precursor RNAs to yield excised intron lariat RNAs, which then invade new genomic DNA sites by reverse splicing.
A. Lambowitz, S. Zimmerly
semanticscholar +1 more source
Cell-type specific analysis of translating RNAs in developing flowers reveals new levels of control [PDF]
, 2010 Determining both the expression levels of mRNA and the regulation of its translation is important in understanding specialized cell functions. In this study, we describe both the expression profiles of cells within spatiotemporal domains of the ...
Elliot M Meyerowitz +4 more
core +2 more sources
Intronic MicroRNA (miRNA) [PDF]
BioMed Research International, 2006 Nearly 97% of the human genome is composed of noncoding DNA, which varies from one species to another. Changes in these sequences often manifest themselves in clinical and circumstantial malfunction. Numerous genes in these non‐protein‐coding regions encode microRNAs, which are responsible for RNA‐mediated gene silencing through RNA interference (RNAi)‐
Shi-Lung Lin +2 more
openaire +2 more sources
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Splicing-related features of introns serve to propel evolution. [PDF]
PLoS ONE, 2013 The role of spliceosomal intronic structures played in evolution has only begun to be elucidated. Comparative genomic analyses of fungal snoRNA sequences, which are often contained within introns and/or exons, revealed that about one-third of snoRNA ...
Yuping Luo +7 more
doaj +1 more source