Results 141 to 150 of about 217,998 (332)

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Effect of 5'UTR introns on gene expression in Arabidopsis thaliana

BMC Genomics, 2006
Background The majority of introns in gene transcripts are found within the coding sequences (CDSs). A small but significant fraction of introns are also found to reside within the untranslated regions (5'UTRs and 3'UTRs) of expressed sequences ...
Simons Cas, Chung Betty YW, Firth Andrew E, Brown Chris M, Hellens Roger P   +4 more
doaj   +1 more source

Integrated evolution of ribosomal RNAs, introns, and intron nurseries [PDF]

Genetica, 2018
The initial components of ribosomes first appeared more than 3.8 billion years ago during a time when many types of RNAs were evolving. While modern ribosomes are complex molecular machines consisting of rRNAs and proteins, they were assembled during early evolution by the association and joining of small functional RNA units. Introns may have provided
openaire   +3 more sources

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Alternative processing of bovine growth hormone mRNA: nonsplicing of the final intron predicts a high molecular weight variant of bovine growth hormone. [PDF]

, 1987
R K Hampson, Fritz Rottman
openalex   +1 more source

Editorial: Genetically mobile elements repurposed by nature and biotechnologists

Frontiers in Molecular Biosciences, 2022
Christopher W. Lennon, Brian P. Callahan, Benoit Cousineau, David R. Edgell, Marlene Belfort   +4 more
doaj   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Replication-induced stimulation of the major late promoter of adenovirus is correlated to the binding of a factor to sequences in the first intron [PDF]

, 1988
Pidder Jansen‐Dürr, Hélène Bœuf, C. Kédinger   +2 more
openalex   +1 more source

Unique features of conventional and nonconventional introns in Euglena gracilis

BMC Genomics
Background Nuclear introns in Euglenida have been understudied. This study aimed to investigate nuclear introns in Euglenida by identifying a large number of introns in Euglena gracilis (E.
Pingwei Gao, Yali Zhao, Guangjie Xu, Yujie Zhong, Chengfu Sun   +4 more
doaj   +1 more source