Results 161 to 170 of about 217,998 (332)
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Advanced Science, EarlyView.Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska +18 more
wiley +1 more source
Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle
Advanced Science, EarlyView.This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia +39 more
wiley +1 more source
Presence of transcription regulatory elements within an intron of the virus-inducible murine TIMP gene. [PDF]
, 1988 Benoit Coulombe +4 more
openalex +1 more source
PIntron: a Fast Method for Gene Structure Prediction via Maximal Pairings of a Pattern and a Text [PDF]
, 2010 Current computational methods for exon-intron structure prediction from a cluster of transcript (EST, mRNA) data do not exhibit the time and space efficiency necessary to process large clusters of over than 20,000 ESTs and genes longer than 1Mb ...
Bonizzoni, Paola +3 more
core
The role of introns in evolution
FEBS Letters, 1990 What are the roles of ‘classical’ introns in the evolution of nuclear genes, and what was the origin of these introns? Exon shuffling has been important in the evolution of cell surface and extracellular proteins, but the evidence for it in respect of intracellular proteins is weak.
openaire +2 more sources
Advanced Science, EarlyView.Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan +19 more
wiley +1 more source
cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: implication for mechanisms of control [PDF]
, 1988 Richard A. Katz +2 more
openalex +1 more source
Identification of the expressome by machine learning on omics data. [PDF]
, 2019 Accurate annotation of plant genomes remains complex due to the presence of many pseudogenes arising from whole-genome duplication-generated redundancy or the capture and movement of gene fragments by transposable elements.
Briggs, Steven P +3 more
core +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source