Results 11 to 20 of about 129,584 (259)
Memorias do Instituto Oswaldo Cruz, 2018 In Cryptococcus neoformans, nearly all genes are interrupted by small introns. In recent years, genome annotation and genetic analysis have illuminated the major roles these introns play in the biology of this pathogenic yeast.
Guilhem Janbon
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Frontiers in Genetics, 2012 The intron-exon architecture of many eukaryotic genes raises the intriguing question of whether this unique organization serves any function, or is it simply a result of the spread of functionless introns in eukaryotic genomes. In this review, we show that introns in contemporary species fulfill a broad spectrum of functions, and are involved in ...
Liran eCarmel +2 more
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Intron “sliding” and the diversity of intron positions [PDF]
Proceedings of the National Academy of Sciences, 1997 Alignments of homologous genes typically reveal a great diversity of intron locations, far more than could fit comfortably in a single gene. Thus, a minority of these intron positions could be inherited from a single ancestral gene, but the larger share must be attributed to subsequent events of intron gain or intron “sliding” (movement from one ...
A, Stoltzfus +3 more
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Splice and Dice: Intronic microRNAs, Splicing and Cancer
Biomedicines, 2021 Introns span only a quarter of the human genome, yet they host around 60% of all known microRNAs. Emerging evidence indicates the adaptive advantage of microRNAs residing within introns is attributed to their complex co-regulation with transcription and ...
Alex C. H. Wong, John E. J. Rasko
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G3: Genes, Genomes, Genetics, 2016 Although RNA-Seq has revolutionized transcript analysis, organellar transcriptomes are rarely assessed even when present in published datasets. Here, we describe the development and application of a rapid and convenient method, ChloroSeq, to delineate ...
Benoît Castandet +3 more
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Can Introns Stabilize Gene Duplication?
Biology, 2022 Gene duplication is considered one of the most important events that determine the evolution of genomes. However, the neo-duplication condition of a given gene is particularly unstable due to recombination events. Several mechanisms have been proposed to
Gioacchino Micheli, Giorgio Camilloni
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Intronization, de-intronization and intron sliding are rare in Cryptococcus [PDF]
BMC Evolutionary Biology, 2009 Eukaryotic pre-mRNA gene transcripts are processed by the spliceosome to remove portions of the transcript, called spliceosomal introns. The spliceosome recognizes intron boundaries by the presence of sequence signals (motifs) contained in the actual transcript, thus sequence changes in the genome that affect existing splicing signals or create new ...
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Intron Mobility: Invasive introns [PDF]
Current Biology, 1994 The evidence that introns in fungal and plant organellar DNAs are mobile genetic elements has strengthened significantly; like Shaw's cockney heroine, Eliza Doolittle, they cannot help but betray their origins.
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Exploring the Relationship between Fusion Genes and MicroRNAs in Cancer
Cells, 2023 Fusion genes are key cancer driver genes that can be used as potential drug targets in precision therapies, and they can also serve as accurate diagnostic and prognostic biomarkers.
Saurav Panicker +4 more
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Molecular Biotechnology, 2011 Eukaryotic gene expression relies on several complex molecular machineries that act in a highly coordinated fashion. These machineries govern all the different steps of mRNA maturation, from gene transcription and pre-mRNA processing in the nucleus to the export of the mRNA to the cytoplasm and its translation.
Skoko, Natasa +3 more
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