Results 31 to 40 of about 129,584 (259)
Non-Coding RNA, 2019 The conservation of intronic sequences was studied in the mitochondrial solute carrier (SLC25A*) genes of Zebrafish, Chicken, Mouse and Human. These genes are homologous and the coding sequences have been well conserved throughout Vertebrates, but the ...
Rosa Calvello +4 more
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Horizontal Transfer and Gene Loss Shaped the Evolution of Alpha-Amylases in Bilaterians
G3: Genes, Genomes, Genetics, 2020 The subfamily GH13_1 of alpha-amylases is typical of Fungi, but it is also found in some unicellular eukaryotes (e.g., Amoebozoa, choanoflagellates) and non-bilaterian Metazoa.
Andrea Desiderato +3 more
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Intron Evolution in Saccharomycetaceae [PDF]
Genome Biology and Evolution, 2014 Introns in protein-coding genes are very rare in hemiascomycetous yeast genomes. It has been suggested that these species have experienced extensive intron loss during their evolution from the postulated intron-rich fungal ancestor. However, no intron-devoidy east species have been identified and some of the introns remaining within the genomes of ...
Hooks, Katarzyna B +2 more
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Dynamics of genomic innovation in the unicellular ancestry of animals
eLife, 2017 Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the ...
Xavier Grau-Bové +6 more
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Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq
eLife, 2017 R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene ...
Jason G Dumelie, Samie R Jaffrey
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Frontiers in Microbiology, 2019 Ciliated protists (ciliates) are widely used for investigating evolution, mostly due to their successful radiation after their early evolutionary branching.
Bo Pan +8 more
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Nucleic Acids Research, 1987 The sequence information for the splicing process of introns is found in the consensus sequences at the two splice sites. For long introns, of 300 or more nucleotides, the middle regions may provide additional specificity for splicing which can be investigated by defining an adequate quantitative parameter.
Arquès DG, Michel CJ
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The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer
Frontiers in Molecular Biosciences, 2018 Alternative splicing allows for the expression of multiple RNA and protein isoforms from one gene, making it a major contributor to transcriptome and proteome diversification in eukaryotes.
Ettaib El Marabti, Ihab Younis
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Taxonomy of introns and the evolution of minor introns
Nucleic Acids ResearchAbstract Classification of introns, which is crucial to understanding their evolution and splicing, has historically been binary and has resulted in the naming of major and minor introns that are spliced by their namesake spliceosome. However, a broad range of intron consensus sequences exist, leading us to here reclassify introns as ...
Anouk M Olthof +9 more
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Analysis of intron sequence features associated with transcriptional regulation in human genes. [PDF]
PLoS ONE, 2012 Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture.
Huimin Li, Dan Chen, Jing Zhang
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