Results 31 to 40 of about 152,197 (251)

Horizontal Transfer and Gene Loss Shaped the Evolution of Alpha-Amylases in Bilaterians

G3: Genes, Genomes, Genetics, 2020
The subfamily GH13_1 of alpha-amylases is typical of Fungi, but it is also found in some unicellular eukaryotes (e.g., Amoebozoa, choanoflagellates) and non-bilaterian Metazoa.
Andrea Desiderato, Marcos Barbeitos, Clément Gilbert, Jean-Luc Da Lage   +3 more
doaj   +1 more source

Dynamics of genomic innovation in the unicellular ancestry of animals

eLife, 2017
Which genomic innovations underpinned the origin of multicellular animals is still an open debate. Here, we investigate this question by reconstructing the genome architecture and gene family diversity of ancestral premetazoans, aiming to date the ...
Xavier Grau-Bové, Guifré Torruella, Stuart Donachie, Hiroshi Suga, Guy Leonard, Thomas A Richards, Iñaki Ruiz-Trillo   +6 more
doaj   +1 more source

Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq

eLife, 2017
R-loops are features of chromatin consisting of a strand of DNA hybridized to RNA, as well as the expelled complementary DNA strand. R-loops are enriched at promoters where they have recently been shown to have important roles in modifying gene ...
Jason G Dumelie, Samie R Jaffrey
doaj   +1 more source

Comparative Genomics Analysis of Ciliates Provides Insights on the Evolutionary History Within “Nassophorea–Synhymenia–Phyllopharyngea” Assemblage

Frontiers in Microbiology, 2019
Ciliated protists (ciliates) are widely used for investigating evolution, mostly due to their successful radiation after their early evolutionary branching.
Bo Pan, Bo Pan, Xiao Chen, Lina Hou, Qianqian Zhang, Zhishuai Qu, Zhishuai Qu, Alan Warren, Miao Miao   +8 more
doaj   +1 more source

Introns

, 2012
Counts of trimmed 36 bp reads that mapped uniquely to consolidated introns of genes annotated in RefSeq for 136 ...
Sinicropi, Dominick, Stephans, James, Dei Rossi, Andrew, Qu, Kunbin, Collin, Francois, Crager, Michael, John Morlan (151332), Pelham, Robert J., Esteban, Jose M., Liu, Mei-Lan, Zheng, Christina, Baker, Joffre, Joffre Baker (20987), Dominick Sinicropi (151288), Jennie Jeong (151310), Mylan Pho (20986), James Stephans (151329), Mena, Raul, Francois Collin (18691), Ranjana Ambannavar (151316), Andrew Dei Rossi (151305), Mei-Lan Liu (151299), Jose M. Esteban (3276027), Kunbin Qu (2660), Aaron Scott (151313), Jeong, Jennie, Scott, Aaron, Christina Zheng (151321), Pho, Mylan, Morlan, John, Michael Crager (151294), Ambannavar, Ranjana, Raul Mena (151324), Robert J. Pelham (131925)   +33 more
core   +1 more source

The Protist Ribosomal Reference database (PR2): a catalog of unicellular eukaryote Small Sub-Unit rRNA sequences with curated taxonomy [PDF]

, 2012
The interrogation of genetic markers in environmental meta-barcoding studies is currently seriously hindered by the lack of taxonomically curated reference data sets for the targeted genes.
Probert, Ian, Dolan, John R., Kooistra, Wiebe H.C.F., Guillou, Laure, Vaulot, Daniel, Campo, Javier, Del, Morard, Raphael, Bass, David, Logares, Ramiro, Montresor, Marina, del Campo, Javier, Lara, Enrique, Berney, Cédric, Zimmermann, Pascal, Burgaud, Gaétan, Pawlowski, Jan, Campo, Javier,, Bachar, Dipankar, Boutte, Christophe, Bittner, Lucie, Christen, Richard, Mahe, Frédéric, Dunthorn, Micah, Kooistra, Wiebe H. C. F., ,, Siano, Raffaele, Stoeck, Thorsten, Le Bescot, Noan, Audic, Stéphane, Decelle, Johan, Not, Fabrice, Massana, Ramon, de Vargas, Colomban, Sauvadet, Anne-Laure, Edvardsen, Bente, Holzmann, Maria   +35 more
core   +1 more source

The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer

Frontiers in Molecular Biosciences, 2018
Alternative splicing allows for the expression of multiple RNA and protein isoforms from one gene, making it a major contributor to transcriptome and proteome diversification in eukaryotes.
Ettaib El Marabti, Ihab Younis
doaj   +1 more source

Analysis of intron sequence features associated with transcriptional regulation in human genes. [PDF]

PLoS ONE, 2012
Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture.
Huimin Li, Dan Chen, Jing Zhang
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source