Results 41 to 50 of about 209,653 (293)

Improved ontology for eukaryotic single-exon coding sequences in biological databases [PDF]

, 2018
Indexación: Scopus.Efficient extraction of knowledge from biological data requires the development of structured vocabularies to unambiguously define biological terms. This paper proposes descriptions and definitions to disambiguate the term 'single-exon
Clausen, P., González, C., Holmes, D.S., Jorquera, R., Petersen, B.   +4 more
core   +2 more sources

Exons, introns and DNA thermodynamics

, 2005
The genes of eukaryotes are characterized by protein coding fragments, the exons, interrupted by introns, i.e. stretches of DNA which do not carry any useful information for the protein synthesis.
A. Stoltzfus, B. Alberts, C. C. F. Blake, D. Poland, D. Poland, Enrico Carlon, K. A. Marx, Mehdi Lejard Malki, N. J. Dibb, Ralf Blossey, W. Gilbert, W. Gilbert   +11 more
core   +1 more source

Mitochondrial genomes of the early land plant lineage liverworts (Marchantiophyta): conserved genome structure, and ongoing low frequency recombination

BMC Genomics, 2019
Background In contrast to the highly labile mitochondrial (mt) genomes of vascular plants, the architecture and composition of mt genomes within the main lineages of bryophytes appear stable and invariant.
Shanshan Dong, Chaoxian Zhao, Shouzhou Zhang, Li Zhang, Hong Wu, Huan Liu, Ruiliang Zhu, Yu Jia, Bernard Goffinet, Yang Liu   +9 more
doaj   +1 more source

In search of lost introns

, 2007
Many fundamental questions concerning the emergence and subsequent evolution of eukaryotic exon-intron organization are still unsettled. Genome-scale comparative studies, which can shed light on crucial aspects of eukaryotic evolution, require adequate ...
Adachi, Aldous, Altschul, Bieri, Blum, Carmel, Collins, Coulombe-Huntington, Csűrös, Csűrös, Devroye, Durbin, Edgar, Felsenstein, Felsenstein, Felsenstein, Friedman, Guindon, Harding, Heard, Hubbard, Igor B. Rogozin, IHBSC, J. Andrew Holey, Jeffares, Kececioglu, Kosakovsky Pond, Larget, Ma, Marchler-Bauer, McDiarmid, McKenzie, Miklós Csűrös, Müller, Nguyen, Nielsen, Nixon, Press, Pruitt, Raible, Rogozin, Rogozin, Rosenberg, Roy, Roy, Roy, Roy, Stamatakis, Steel, Sverdlov, Sverdlov, Tatusov, Vaňácová, Zhang   +53 more
core   +1 more source

Improving the Caenorhabditis elegans Genome Annotation Using Machine Learning [PDF]

, 2007
For modern biology, precise genome annotations are of prime importance, as they allow the accurate definition of genic regions. We employ state-of-the-art machine learning methods to assay and improve the accuracy of the genome annotation of the nematode
Bernhard Schölkopf, Gunnar Rätsch, Hanh Witte, Jagan Srinivasan, Klaus-R Müller, Ralf-J Sommer, Sören Sonnenburg, The Caenorhabditis elegans sequencing consortium, Uwe Ohler   +8 more
core   +6 more sources

Non-coding parts of genomes as the basis of epigenetic heredity

Вавиловский журнал генетики и селекции, 2017
We hypothesized that the basis of epigenetic regulation of genomes in ontogenesis is the specificity of the distribution, number and composition of transposons. Transposons constitute the major part of the genomes of multicellular eukaryotes.
R. N. Mustafin, E. K. Khusnutdinova
doaj   +1 more source

An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation [PDF]

, 2017
Global transcriptome reprogramming during sper-matogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Sper-matocytes and spermatids require particularly exten-sive reprogramming of gene expression to switch from
Alberdi, Antonio J., Bielli, Pamela, De la Grange, Pierre, DI PERSIO, Sara, Geremia, Raffaele, Jolly, Ariane, Naro, Chiara, Sette, Claudio, Setterblad, Niclas, Vicini, Elena   +9 more
core   +2 more sources

Imaging Intron Evolution

Methods and Protocols, 2022
Intron evolution may be readily imaged through the combined use of the “dot plot” function of the NCBI BLAST, aligning two sequences at a time, and the Vertebrate “Multiz” alignment and conservation tool of the UCSC Genome Browser. With the NCBI BLAST, an ideal alignment of two highly conserved sequences generates a diagonal straight line in the plot ...
Maria Antonietta Panaro, Rosa Calvello, Daniela Valeria Miniero, Vincenzo Mitolo, Antonia Cianciulli   +4 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Analysis of intron sequence features associated with transcriptional regulation in human genes. [PDF]

PLoS ONE, 2012
Although some preliminary work has revealed the potential transcriptional regulatory function of the introns in eukaryotes, additional evidences are needed to support this conjecture.
Huimin Li, Dan Chen, Jing Zhang
doaj   +1 more source