Results 41 to 50 of about 292,600 (397)
Rapidly evolving protointrons in Saccharomyces genomes revealed by a hungry spliceosome. [PDF]
, 2019 Introns are a prevalent feature of eukaryotic genomes, yet their origins and contributions to genome function and evolution remain mysterious. In budding yeast, repression of the highly transcribed intron-containing ribosomal protein genes (RPGs ...
Ares, Manuel +8 more
core +1 more source
Taxonomy of introns and the evolution of minor introns [PDF]
Nucleic Acids ResearchAbstract Classification of introns, which is crucial to understanding their evolution and splicing, has historically been binary and has resulted in the naming of major and minor introns that are spliced by their namesake spliceosome. However, a broad range of intron consensus sequences exist, leading us to here reclassify introns as ...
Anouk M Olthof +9 more
openaire +3 more sources
Nearest neighbour spacing distribution of basis in some intron-less and intron-containing DNA sequences [PDF]
Physica A 372 (2006) 368-373, 2006 We show that the nearest neighbour distribution of distances between basis pairs of some intron-less and intron-containing coding regions are the same when a procedure, called {\em unfolding}, is applied. Such a procedure consists in separating the secular variations from the oscillatory terms.
arxiv +1 more source
BMC Genomics, 2019 Mutations in minor spliceosome components such as U12 snRNA (cerebellar ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1)) result in tissue-specific symptoms.
Anouk M Olthof +2 more
semanticscholar +1 more source
Strong Purifying Selection at Synonymous Sites in D. melanogaster [PDF]
, 2013 Synonymous sites are generally assumed to be subject to weak selective constraint. For this reason, they are often neglected as a possible source of important functional variation.
Hershberg, Ruth +3 more
core +7 more sources
Intron exclusion and the mystery of intron loss [PDF]
FEBS Letters, 2006 Mechanisms for loss and gain of introns are elusive. Reported here is a new pattern of intron loss which features a random loss of a single intron in a multiple‐intron gene with its neighboring introns remained, which process is defined as intron exclusion.
openaire +3 more sources
Intron-mediated enhancement is not limited to introns [PDF]
, 2018 AbstractCertain introns strongly increase mRNA accumulation by a poorly understood mechanism known as Intron-Mediated Enhancement (IME). Introns that boost expression by IME have no effect when located upstream of or more than ~1 Kb downstream from the start of transcription.
Gallegos, Jenna E, Rose, Alan B
openaire +1 more source
Most human introns are recognized via multiple and tissue-specific branchpoints
Genes & Development, 2018 Pineda and Bradley demonstrate that almost all human introns contain multiple branchpoints. Approximately three-quarters of constitutive introns exhibit tissue-specific branchpoint usage.
Jose Mario Bello Pineda, R. Bradley
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2016 Although RNA-Seq has revolutionized transcript analysis, organellar transcriptomes are rarely assessed even when present in published datasets. Here, we describe the development and application of a rapid and convenient method, ChloroSeq, to delineate ...
Benoît Castandet +3 more
doaj +1 more source
tRNA-isoleucine-tryptophan Composite Gene [PDF]
Biochemical and biophysical Research Communications 339 (2005)
37-40, 2005 Transfer-RNA genes in archaea often have introns intervening between exon sequences. The structural motif at the boundary between exon and intron is the bulge-helix-bulge. Computational investigations of these boundary structures in H. marismortui lead us to propose that tRNA-isoleucine and tRNA-tryptophan genes are co-located.
arxiv +1 more source