Results 81 to 90 of about 208,052 (306)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Data Pre-Processing and Classification for Traffic Anomaly Intrusion Detection Using NSLKDD Dataset
Cybernetics and Information Technologies, 2018 Network security is essential in the Internet world. Intrusion Detection is one of the network security components. Anomaly Intrusion Detection is a type of intrusion detection that captures the intrinsic characteristics of normal data and uses it in the
Gnanaprasanambikai L. +1 more
doaj +1 more source
Research on Key Technology of Network Intrusion Detection System Based on Improved GA-BPNN Algorithm
Chemical Engineering Transactions, 2016 In recent years, with the rapid development of information and network technology, computer and network infrastructure has become a popular target of hacker attacks.
H.F. Hu, W.N. He
doaj +1 more source
Molecular Oncology, EarlyView.The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat +18 more
wiley +1 more source
A cognitive based Intrusion detection system
, 2020 Intrusion detection is one of the primary mechanisms to provide computer networks with security. With an increase in attacks and growing dependence on various fields such as medicine, commercial, and engineering to give services over a network, securing ...
Menhaj, Mohammad Bagher +1 more
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source