Results 111 to 120 of about 993,133 (247)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Caracterización de cepas de Listeria monocytogenes realizados a partir de queso fresco proveniente de diferentes zonas productoras costarricenses Characterization of Listeria monocytogenes isolates obtained from raw cheese samples acquired from different Costa Rican producer zones

Archivos Latinoamericanos de Nutrición, 2009
En Costa Rica, cerca del 25% de la producción de leche nacional es utilizada en la elaboración de queso tierno no pasteurizado, y el consumo de este producto es aproximadamente de 4 a 5 kg anuales per cápita.
Carolina Cháves, María Laura Arias
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TELMA: Entorno de formación personalizada online en Cirugía de Mínima Invasión [PDF]

, 2010
TELMA es un entorno de formación y aprendizaje online basado en edición de vídeo laparoscópico, la gestión del conocimiento y el trabajo colaborativo con el fin de mejorar la efectividad y eficacia de los procesos de formación (inicial y continuada ...
Albacete, A., Asenjo, E., Burgos, D., Fernández Pérez, Antonio José, Gómez Aguilera, Enrique J., Noguera Aguilar, Jose, Oropesa García, Ignacio, Sánchez González, Patricia, Sánchez Margallo, Francisco Miguel   +8 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Factores pronósticos en el tratamiento quirúrgico de las metástasis pulmonares [PDF]

, 2016
En este trabajo se han revisado los factores que determinan el pronóstico de los pacientes con metástasis pulmonares de cáncer colorrectal. Para ello se han revisado artículos científicos que evalúan factores más conocidos como número de metástasis, el ...
Bailón Cuadrado, Cristina
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

A new record for American Bullfrog (Lithobates catesbeianus) in San Juan, Argentina Nuevo registro de rana toro americana (Lithobates catesbeianus) en San Juan, Argentina

Revista Mexicana de Biodiversidad, 2011
We report a new record of Lithobates catesbeianus (American bullfrog) from Argentina. L. catesbeianus was first introduced to San Juan Province 11 years ago in Calingasta Department, where the habitat is pre-cordilleran.
Eduardo Sanabria, Yanina Ripoll, Marcelo Jordan, Lorena Quiroga, Mariano Ariza, María Guillemain, Mauricio Pérez, Héctor Chávez   +7 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

EL IMAGINARIO DE LA INFANCIA EN LOS POETAS DE CHIPRE ANTE LA INVASIÓN TURCA DE 1974 The imaginary of infancy in the Turkish invasion of 1974

Byzantion Nea Hellás, 2009
En el presente artículo, el profesor César García presenta en primer lugar un breve panorama de la última historia de Chipre, posteriormente ahonda en el imaginario de los niños en la poesía grecochipriota a partir de la invasión del974.
César García Álvarez
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