Results 41 to 50 of about 811,172 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Clinical significance of preoperative serum VEGF in predicting metachronous liver metastasis of colorectal cancer: development of a novel nomogram

World Journal of Surgical Oncology
Background Metachronous liver metastasis (MLM) after primary resection of colorectal cancer (CRC) substantially worsens patient prognosis. Vascular endothelial growth factor (VEGF) is a highly bioactive proangiogenic protein.
Yufei Gu, Jin Du, Yanxin Zhao, Zhongwen Sun, Haijian Yang, Libing Yang, Zhenzhen Cao, Xintao Wang   +7 more
doaj   +1 more source

Tumor neoantigen gene C7orf50 remodels the immune microenvironment by recruiting tumor-associated macrophages to promote hepatocellular carcinoma progression and lung metastasis

Journal for ImmunoTherapy of Cancer
Background Hepatocellular carcinoma (HCC) is a global health challenge with high mortality rates, particularly in patients with advanced disease and lung metastasis.
Xiaowu Huang, Zhiqiang Hu, Yu Gong, Jia Li, Feng Qi, Hecheng Li, Li Mao, Changzhou Chen, Sheng Su, Xinming Ye, Zehuan Li   +10 more
doaj   +1 more source

Extracellular matrix collagen I promotes the tumor progression of residual hepatocellular carcinoma after heat treatment

BMC Cancer, 2018
Background Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellular matrix (ECM) in modulating the
Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen   +9 more
doaj   +1 more source

MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming

Journal of Hematology & Oncology, 2020
Background MicroRNA-612 (miR-612) has been proven to suppress EMT, stemness, and tumor metastasis of hepatocellular carcinoma (HCC) via PI3K/AKT2 and Sp1/Nanog signaling. However, its biological roles on HCC progression are far from elucidated.
Yang Liu, Li-Li Lu, Duo Wen, Dong-Li Liu, Li-Li Dong, Dong-Mei Gao, Xin-Yu Bian, Jian Zhou, Jia Fan, Wei-Zhong Wu   +9 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Activated hepatic stellate cells promote progression of post-heat residual hepatocellular carcinoma from autophagic survival to proliferation

International Journal of Hyperthermia, 2019
Background: Microscopic residual tumor often occurs after thermal ablation for medium-large hepatocellular carcinoma (HCC), leading to early aggressive recurrence or late relapse during follow-up.
Rui Zhang, Xia-Hui Lin, Hua-Hua Liu, Min Ma, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Rong-Xin Chen   +8 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Association of hepatitis status with surgical outcomes in patients with dual hepatitis B and C related hepatocellular carcinoma

Infectious Agents and Cancer, 2017
Background The conception that serological hepatitis markers determined surgical prognosis of hepatocellular carcinoma (HCC) associated with hepatitis B (HBV) or hepatitis C (HCV) has been well defined.
Xiu-Tao Fu, Ying-Hong Shi, Jian Zhou, Yuan-Fei Peng, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Kang Song, Jia Fan, Zhen-Bin Ding   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source