Results 81 to 90 of about 3,622,938 (386)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Symmetric competition as a general model for single-species adaptive dynamics

, 2012
Adaptive dynamics is a widely used framework for modeling long-term evolution of continuous phenotypes. It is based on invasion fitness functions, which determine selection gradients and the canonical equation of adaptive dynamics.
Doebeli, Michael, Ispolatov, Iaroslav
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Growth activity during fingering in a porous Hele Shaw cell [PDF]

, 2003
We present in this paper an experimental study of the invasion activity during unstable drainage in a 2D random porous medium, when the (wetting) displaced fluid has a high viscosity with respect to that of the (non-wetting) displacing fluid, and for a ...
Lovoll, Grunde, Maloy, Knut Jorgen, Meheust, Yves, Schmittbuhl, Jean, Toussaint, Renaud   +4 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Invasive and non-invasive monitoring in the ICU

Trauma Surgery & Acute Care Open
Effective invasive and non-invasive monitoring, when coupled with good clinical decision making, can improve outcomes for critically ill patients. When deciding on the best monitoring technique, it is important to consider the specific information that is needed to guide critical care management, while balancing the reliability of the data obtained and
Kendall R McEachron, Todd W Costantini
openaire   +3 more sources

Mapping the global state of invasive alien species: patterns of invasion and policy responses

, 2017
Aim To use global databases to (1) provide a visualization of global geographical patterns of species invasions, origins and pathways and (2) depict the international uptake of legislative and policy responses to invasive alien species (IAS ...
Anna J. Turbelin, B. Malamud, R. Francis
semanticscholar   +1 more source

Prioritizing species, pathways, and sites to achieve conservation targets for biological invasion

Biological Invasions, 2016
Prioritization is indispensable for the management of biological invasions, as recognized by the Convention on Biological Diversity, its current strategic plan, and specifically Aichi Target 9 that concerns invasive alien species.
M. McGeoch, P. Genovesi, P. Bellingham, Mark John Costello, C. McGrannachan, A. Sheppard   +5 more
semanticscholar   +1 more source

Combining local- and large-scale models to predict the distributions of invasive plant species [PDF]

, 2010
Habitat-distribution models are increasingly used to predict the potential distributions of invasive species and to inform monitoring. However, these models assume that species are in equilibrium with the environment, which is clearly not true for most ...
Acker, Steven A., Halpern, Charles B., Jones, Chad C.   +2 more
core   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source