Results 101 to 110 of about 304,649 (268)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Taming the terminological tempest in invasion science [PDF]

Standardised terminology in science is important for clarity of interpretation and communication. In invasion science – a dynamic and rapidly evolving discipline – the proliferation of technical terminology has lacked a standardised framework for its ...
Glavendekic, M.M., Simberloff, D., Meshkova, V., Patoka, J., Florencio, M., Soto, I., Britton, J.R., Zenni, R.D., South, J., Oficialdegui, F.J., López‐López, E., Cano‐Barbacil, C., Yapıcı, S., Bradshaw, C.J.A., Macêdo, R., Falk‐Andersson, J., Nuñez, M.A., Ahmed, D.A., Bacela‐Spychalska, K., Piria, M., Stoett, P., Buřič, M., Vilizzi, L., Musolin, D.L., Dick, J.T.A., Balzani, P., Camacho‐Cervantes, M., Kirichenko, N.I., Fernandez, R.D., Bortolus, A., De Santis, V., Pattison, Z., Coughlan, N.E., Sanchez, A.E., Carneiro, L., Weiperth, A., Cuthbert, R.N., Rilov, G., Baudry, T., Milardi, M., Wang, Y., Watari, Y., Liu, C., Lozano, V., Ballesteros‐Mejia, L., Franco, A.C.S., Kourantidou, M., Dimarco, R.D., Courtois, P., Herrera, I., Robinson, T.B., Lipták, B., Kurtul, I., Mammola, S., Briski, E., Probert, A.F., Russell, J.C., Marchini, A., Wehi, P.M., Wiberg‐Larsen, P., Laufer, G., Grabowski, M., Ricciardi, A., Rasmussen, J.J., Huang, W., Schwindt, E., Galil, B.S., Renault, D., Bang, A., Dalu, T., Bailey, S.A., Csabai, Z., Dickey, J.W.E., Verreycken, H., Yoğurtçuoğlu, B., Serhan Tarkan, A., Haubrock, P.J., Pincheira‐Donoso, D., Copilaș‐Ciocianu, D., Giannetto, D., Ribeiro, F., Heringer, G., García‐Berthou, E., Kamelamela, K.L., Kouba, A.   +84 more
core   +1 more source

Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation

Journal of Experimental & Clinical Cancer Research, 2018
Background Higher matrix stiffness affects biological behavior of tumor cells, regulates tumor-associated gene/miRNA expression and stemness characteristic, and contributes to tumor invasion and metastasis.
Sifan Wu, Qiongdan Zheng, Xiaoxia Xing, Yinying Dong, Yaohui Wang, Yang You, Rongxin Chen, Chao Hu, Jie Chen, Dongmei Gao, Yan Zhao, Zhiming Wang, Tongchun Xue, Zhenggang Ren, Jiefeng Cui   +14 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Microvascular Invasion In Hepatocellular Carcinoma [PDF]

, 2016
Microvascular invasion is a crucial histopathologic prognostic factor for hepatocellular carcinoma. We reviewed the literature and aimed to draw attention to clinicopathologic and imaging findings that may predict the presence of microvascular invasion ...
Akata, Deniz, Ozmen, Mustafa Nasuh, Karcaaltincaba, Musturay, Mustafa Nasuh Özmen, Unal, Emre, Deniz Akata, Emre Ünal, Muşturay Karçaaltıncaba, İlkay Sedakat İdilman, Idilman, Ilkay Sedakat   +9 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Contributions to the National Status Report on Biological Invasions in South Africa

Bothalia: African Biodiversity & Conservation, 2017
South Africa has committed to producing a National Status Report on Biological Invasions by October 2017 and thereafter every three years. This will be the first status report at a national level specifically on biological invasions.
John R.U. Wilson, Mirijam Gaertner, David M. Richardson, Brian W. van Wilgen   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Understanding and classifying the raw water transfer invasion pathway [PDF]

Raw Water Transfer (RWT) schemes move large volumes of freshwater between separate waterbodies to supply water as a specific commodity. Water is translocated by complex purpose-built networks of pipelines, tunnels and water supply canals.
Waine, Ava, Pattison, Zarah, Robertson, Peter   +2 more
core   +1 more source