Results 111 to 120 of about 1,492,047 (368)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Contributions to the National Status Report on Biological Invasions in South Africa

Bothalia: African Biodiversity & Conservation, 2017
South Africa has committed to producing a National Status Report on Biological Invasions by October 2017 and thereafter every three years. This will be the first status report at a national level specifically on biological invasions.
John R.U. Wilson, Mirijam Gaertner, David M. Richardson, Brian W. van Wilgen   +3 more
doaj   +1 more source

Microvascular Invasion In Hepatocellular Carcinoma [PDF]

, 2016
Microvascular invasion is a crucial histopathologic prognostic factor for hepatocellular carcinoma. We reviewed the literature and aimed to draw attention to clinicopathologic and imaging findings that may predict the presence of microvascular invasion ...
Akata, Deniz, Ozmen, Mustafa Nasuh, Karcaaltincaba, Musturay, Mustafa Nasuh Özmen, Unal, Emre, Deniz Akata, Emre Ünal, Muşturay Karçaaltıncaba, İlkay Sedakat İdilman, Idilman, Ilkay Sedakat   +9 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Ultrahigh-speed non-invasive widefield angiography [PDF]

, 2012
Cédric Blatter, Thomas Klein, Branislav Grajciar, Tilman Schmoll, Wolfgang Wieser, Raphaël André, Robert Huber, Rainer A. Leitgeb   +7 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Breast Cancer Research, 2017
Background Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epithelial transition (MET).
H. J. Hugo, N. P. A. D. Gunasinghe, B. G. Hollier, T. Tanaka, T. Blick, A. Toh, P. Hill, C. Gilles, M. Waltham, E. W. Thompson   +9 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A fine-scale assessment of the ecosystem service-disservice dichotomy in the context of urban ecosystems affected by alien plant invasions

Forest Ecosystems, 2019
Background Natural resources within and around urban landscapes are under increasing pressure from ongoing urbanisation, and management efforts aimed at ensuring the sustainable provision of ecosystem services (ES) are an important response.
Luke J. Potgieter, Mirijam Gaertner, Patrick J. O’Farrell, David M. Richardson   +3 more
doaj   +1 more source

Understanding and classifying the raw water transfer invasion pathway [PDF]

Raw Water Transfer (RWT) schemes move large volumes of freshwater between separate waterbodies to supply water as a specific commodity. Water is translocated by complex purpose-built networks of pipelines, tunnels and water supply canals.
Waine, Ava, Pattison, Zarah, Robertson, Peter   +2 more
core   +1 more source