Results 61 to 70 of about 43,265 (297)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Understanding the role of clonal integration in plant invasions: an experimental study with "Carpobrotus sp." [PDF]

, 2015
[Resumen] Las invasiones biológicas representan una de las principales amenazas para la conservación de la biodiversidad. Los mecanismos implicados en las invasiones biológicas son actualmente un tema muy estudiado en ecología.
Portela Carballeira, Rubén
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sobre la complejidad de las invasiones indoeuropeas en nuestra Península

Zephyrus, 2009
La comparación de las invasiones indoeuropeas de la Edad del Hierro en la Penínsua, con las posteriores invasiones germánicas, por ejemplo, es bastante provechosa, y ella bastará para mostrarnos, con el caso de los alanos, que toda invasión arrastra ...
Antonio TOVAR LLORENTE
doaj  

Presencia de Chroanta ornatula (Herrich-Schaeffer) (Heteroptera: Pentatomidae) en Sudamérica

Revista Chilena de Entomología, 2019
Se presenta el primer registro en Sudamérica de la especie exótica invasora Chroanta ornatula (Herrich-Schaeffer, 1842) (Heteroptera: Pentatomidae), a partir de 63 ejemplares adultos capturados en la ciudad de Coro, región semiárida del Estado Falcón, al
Dalmiro Cazorla-Perfetti, Pedro Morales-Moreno   +1 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Invasiones biológicas

, 2010
Premeditado o involuntario, el transporte e introducción de especies biológicas fuera de su área nativa es tan antiguo como la propia humanidad. El rápido aumento en el tránsito de personas y mercancías ligado a la creciente globalización ha multiplicado, sin embargo, la escala espacial de las introducciones, y el número de organismos que se ...
Alcalde, José Luis, Alonso, Álvaro, Andreu, Jara, Aragonés, David, Ayensa, Garbiñe, Ballesteros, Enric, Ballesteros, Enric, Bartomeus, Ignasi, Binimelis, Rosa, Bustamante, Javier, Campos, Juan Antonio, Caño, Lidia, Carrete, Martina, Castro, Pilar, Castro, Silvia, Cerdá, Xim, Costa, Margarita, Dana, Elías D., Delibes de Castro, Miguel, Díaz-Delgado, Ricardo, Díaz-Paniagua, Carmen, García-Berthou, Emili, Gassó, Núria, Godoy, Óscar, Green, Andy J., Herrera, Mercedes, Hidalgo, Judith, Marchante, Elizabete, Marchante, Hélia, Martínez-Alier, Joan, Mateo, José Antonio, Morales, Carolina Laura, Munné, Antoni, Navarro, Luis, Nebot, Borja, Nogales, Manuel, Ortega, Fernando, Tella, José Luis, Vivas, Soledad   +38 more
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Diatomeas: bioindicación en aguas dulces e invasiones biológicas [PDF]

, 2015
Conferencia invitadaComo factores esenciales para la determinación del estado ecológico de los ecosistemas acuáticos, la Directiva Marco del Agua establece, en el anexo V, el uso de comunidades de organismos como bioindicadores de la calidad de las aguas
Blanco Lanza, Saúl
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source