Results 81 to 90 of about 598 (250)

Invasive species modulate the structure and stability of a multilayer mutualistic network. [PDF]

Proc Biol Sci, 2023
Vitali A, Ruiz-Suarez S, Vázquez DP, Schleuning M, Rodríguez-Cabal MA, Sasal Y, Pilosof S.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

La privilegiada artillería

Investigaciones y Ensayos, 2012
Para tener en cuenta la significación de la cuestión propuesta, es sabido que las erogaciones militares en el Virreinato fueron cuantiosas y, como sostiene un estudioso, “representaron generalmente la mitad de todos los gastos reales”?
Enrique Rodolfo Dick
doaj   +2 more sources

The Upper Range Limit of Alien Plants Is Not in Equilibrium with Climate in the Andes of Central Chile. [PDF]

Plants (Basel), 2022
Goncalves E, Herrera I, Alexander J, Duarte M, Cavieres LA, Morales-Salinas L, Bustamante RO.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Numerales indoeuropeos en Hispania

Zephyrus, 2009
Vamos a examinar algún material lingüístico indoeuropeo en la onomástica personal y geográfica de nuestra Península, con la esperanza de lograr algunos indicios sobre la naturaleza y composición de las invasiones, problema hoy candente para arqueólogos ...
Antonio TOVAR LLORENTE
doaj  

Think globally, measure locally: The MIREN standardized protocol for monitoring plant species distributions along elevation gradients. [PDF]

Ecol Evol, 2022
Haider S, Lembrechts JJ, McDougall K, Pauchard A, Alexander JM, Barros A, Cavieres LA, Rashid I, Rew LJ, Aleksanyan A, Arévalo JR, Aschero V, Chisholm C, Clark VR, Clavel J, Daehler C, Dar PA, Dietz H, Dimarco RD, Edwards P, Essl F, Fuentes-Lillo E, Guisan A, Gwate O, Hargreaves AL, Jakobs G, Jiménez A, Kardol P, Kueffer C, Larson C, Lenoir J, Lenzner B, Padrón Mederos MA, Mihoc M, Milbau A, Morgan JW, Müllerová J, Naylor BJ, Nijs I, Nuñez MA, Otto R, Preuk N, Ratier Backes A, Reshi ZA, Rumpf SB, Sandoya V, Schroder M, Speziale KL, Urbach D, Valencia G, Vandvik V, Vitková M, Vorstenbosch T, Walker TWN, Walsh N, Wright G, Zong S, Seipel T.   +57 more
europepmc   +1 more source

Las invasiones indoeuropeas, problema estratigr?fico

Zephyrus, 1957
Los ling?istas, en el tema de las invasiones indoeuropeas en la Pen?nsula, hemos llegado, despu?s de casi medio siglo de investigaciones, a algunas conclusiones que parecen seguras. Naturalmente que la cr?tica de los arque?logos y la aportaci?n por ellos de nuevos datos, puede obligar a reajustes y revisiones, pero en general m?s bien cabe esperar ...
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source