Results 51 to 60 of about 9,601 (268)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Age-Stage, Two-Sex Life Table of Leptinotarsa decemlineata (Coleoptera: Chrysomelidae) Experiencing Cadmium Stress

Insects
Cadmium in agricultural soils has emerged as a substantial threat to crop health and yields through its bioaccumulation along the food chain, with further repercussions for the growth, development, and population dynamics of herbivorous insects.
Bingyu He, Jiebo Zhang, Yang Hu, Yi Zhang, Jianan Wang, Chao Li   +5 more
doaj   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Effect of nanoparticles on the growth of okra cultivated in soil affected by rocky desertification

Scientific Reports
This study investigated the influence of various nanoparticles (NPs), including carbon-based NPs, Al2O3-NPs, SiO2-NPs, and TiO2-NPs, on the growth and physiology of okra plants cultivated in soil impacted by rocky desertification.
Jiyue Wang, Xiaojian Tian, Shuai Wei, Xiuhuan Meng, Nian Chen, Denghong Shi, Chenggang Liang   +6 more
doaj   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Identification and Functional Characterization of Chitinase Genes During Larva–Pupa–Adult Transitions in Tuta absoluta

Insects
Chitinases are crucial in the molting process of insects and represent potential targets for the development of RNA interference (RNAi)-based insecticidal strategies.
Kangkang Xu, Yue Wang, Shuyan Yan, Fanghao Wan, Guy Smagghe, Wenjia Yang   +5 more
doaj   +1 more source

Distribution Status for the Plants of Alien Species on the Baekdudaegan Protected Area, South Korea [PDF]

Geo Data
This study was conducted to provide information on alien species to the Baekdudaegan Protected Area eco-survey by Ministry of Environment in South Korea from 2015 to 2019. The scope of the survey is based on data from 26 subsections out of 44 subsections
Hyungsoo Seo, Hyun-Su Hwang, Hyun-Chul Shin, Daeun Kim, Donghui Choi, Youngjun Park   +5 more
doaj   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Effects of nano oxide particles on the growth and photosynthetic characteristics of okra plant under water deficiency

Folia Horticulturae
Drought, as abiotic stress, has significant detrimental effects on the growth, physiology, yield and nutritional quality of plants. The distinctive characteristics of nanoparticles (NPs) significantly contribute to essential physiological processes ...
Wang Jiyue, Xu Jiajun, Xie Rongrong, Chen Nian, Yang Mingli, Tian Xiaojian, Shi Denghong   +6 more
doaj   +1 more source

Comprehensive assessment of Erwinia amylovora: from establishment risk in global host production areas to dispersal dynamics and associated economic losses in China

Frontiers in Plant Science
Erwinia amylovora is the bacterial pathogen that causes fire blight and is considered one of the most important plant pathogenic bacteria in the world, posing a serious threat to pear and apple production. However, majority of the current risk assessment
Ming Li, Xiaoqing Xian, Zhenan Jin, Yuhan Qi, Jianyang Guo, Nianwan Yang, Nianwan Yang, Guifen Zhang, Jin Xu, Wanxue Liu   +9 more
doaj   +1 more source