Results 101 to 110 of about 91,240 (240)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Transforming Brain Health With Neurotechnology Convergence (Part II): Intelligent Neurointervention Systems for Neurological Disorders

Brain Health, EarlyView.
ABSTRACT Neurological disorders represent a critical domain within global health, necessitating advanced interventions to address complex pathologies such as tumors, functional disorders, and cerebrovascular diseases. Despite the proven benefits of early intervention, current treatment paradigms face significant challenges: (1) limited precision in ...
Qing Ye, Fei Peng, Chao Pan, Ping Zhang, Xuewei Xie, Zixiao Li, Yingxin Tang, Danyang Chen, Yuanwei Li, Jiawen Wu, Zao Han, Qing Dai, Quansheng Gu, Jizong Zhao, Zhouping Tang   +14 more
wiley   +1 more source

Application of nurse⁃led chest physiotherapy guided by lung ultrasound in mechanically ventilated patients

Huli yanjiu
ObjectiveTo analyze the application effect of nurse⁃led chest⁃lung physiotherapy （CPT） guided by lung ultrasound in patients with invasive mechanical ventilation.MethodA total of 70 adult critically ill patients with invasive mechanical ventilation time ≥
YANG Na'na, ZENG Hui, ZHOU Jing, WAN Jie, GAO Fei, CHEN Fang, CHEN Deyou   +6 more
doaj  

A Systemic Model for Understanding Business Interactions With Biodiversity and Ecosystems

Business Strategy and the Environment, EarlyView.
ABSTRACT Biodiversity loss and ecosystem degradation represent critical threats to human well‐being and economic resilience, challenging businesses to understand and manage their interdependence with natural systems. This study develops a systemic framework—the BioModel—that elucidates the reciprocal relationship between businesses, biodiversity, and ...
Lino Cinquini, Giacomo Pigatto, Andrea Tenucci   +2 more
wiley   +1 more source

Mapping health-related quality of life of children and families receiving pediatric invasive home mechanical ventilation: a scoping review protocol

Systematic Reviews
Background Children utilizing invasive home mechanical ventilation (administered via tracheostomy tube) receive intensive care at home without the support of trained staff typically present in an intensive care unit; within the context of worsening home ...
Keisha White Makinde, Maysara Mitchell, Alexandra F. Merz, Michael Youssef   +3 more
doaj   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Status quo and influencing factors of oral health of ICU patients with invasive mechanical ventilation from tertiary hospitals in the Guangxi Zhuang Autonomous Region

Huli yanjiu
ObjectiveTo investigate the status quo of oral health of ICU patients with invasive mechanical ventilation from tertiary hospitals in Guangxi Zhuang Autonomous Region，and to analyze its influencing factors.MethodsA total of 204 ICU patients with invasive
TANG Long, ZHANG Yuanhui, LU Cuiyi, WEI Chunsong, XU Yong, LIANG Meijuan, ZHOU Chunfeng, ZHENG Baifang, WEI Yanchun   +8 more
doaj  

Synergistic Enhancement of Modified‐PVDF Humidity Sensitivity via Chemical Adsorption‐Ionic Conductivity and its Application in Intelligent Powered Air‐Purifying Respirator

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The study developed a PVDF/SiO2 humidity sensor with superhydrophobic properties and integrated the humidity sensor into the intelligent powered air‐purifying respirator (IPAPR) for breath monitoring. Coupled with the Gated Recurrent Unit (GRU) machine learning prediction algorithm, it enables feedforward control of the fan to achieve respiratory ...
Xinjian He, Hongwei Liu, Xianjie Xu, Xinkai Qi, Danhong Gao, Hanling Deng, Dusong Hou, Qianyao Lu, Lei Zhu, Sheng Huang   +9 more
wiley   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

Successful noninvasive mechanical ventilation in a child on prolonged and life-threatening invasive mechanical ventilation after Fontan operation

The Turkish Journal of Pediatrics, 2014
For many decades, the primary treatment of acute respiratory failure has been mechanical ventilation. Intubation and mechanical ventilation carry complications such as upper respiratory system trauma, barotrauma, volutrauma, oxytrauma ...
Ayhan Yaman, Tanıl Kendirli, Çağlar Ödek, Cem Karadeniz, Tayfun Uçar, Gülnur Göllü, Zeynep Eyileten, Erdal İnce   +7 more
doaj