Results 81 to 90 of about 3,338,677 (297)

A Pathology‐Instructed Theranostic Platform with Mechanoadaptive and ROS‐Powered Nanobreathing Functions for Precision Myocardial Repair

Advanced Science, EarlyView.
We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo, Cui Yang, Liuzhou Mao, Panqin Ma, Chiyu Jia, Karen Yuanting Tang, Xian Jun Loh, Yun‐Long Wu   +7 more
wiley   +1 more source

High tidal volume ventilation is not deleterious in infant rats exposed to severe hemorrhage [PDF]

, 2010
BACKGROUND: Both high tidal volume (VT) ventilation and hemorrhage induce acute lung injury in adult rodents. It is not known whether injurious ventilation augments lung injury in infant rats exposed to severe hemorrhage.
Nicholls, Philip K., Sly, P.D., Hantos, Z, Sly, Peter D., Berry, L.J., Cannizzaro, V; https://orcid.org/, Hantos, Zoltán, Cannizzaro, V., Berry, Luke J., Nicholls, P.K., Hantos, Z., Nicholls, P K, Sly, P D, Berry, L J, Cannizzaro, Vincenzo   +14 more
core   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure.

PLoS ONE, 2020
PurposeThe outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and outcomes of patients with COVID-19 managed with invasive mechanical ventilation in an ...
Christopher S King, Dhwani Sahjwani, A Whitney Brown, Saad Feroz, Paula Cameron, Erik Osborn, Mehul Desai, Svetolik Djurkovic, Aditya Kasarabada, Rachel Hinerman, James Lantry, Oksana A Shlobin, Kareem Ahmad, Vikramjit Khangoora, Shambhu Aryal, A Claire Collins, Alan Speir, Steven Nathan   +17 more
doaj   +1 more source

Reproducibility of respiratory mechanics measurements in patients on invasive mechanical ventilation

Revista Brasileira de Terapia Intensiva, 2020
To evaluate the intra- and interexaminer reproducibility of measurements of the resistance and static and dynamic compliance of the respiratory system in patients on mechanical ventilation.This was an analytical study conducted with individuals aged ≥ 18 years who were on invasive mechanical ventilation and had no clinical diagnosis of respiratory ...
Menezes Júnior, José da Natividade, Silva, Ludmilla Mota, Santos, Leonardo José Morais, Correia, Helena França, Lopes, Wende, Silva, Virgínia Eugênia Pinheiro e, dos Anjos, Jorge Luis Motta, Martinez, Bruno Prata   +7 more
openaire   +2 more sources

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Long-term Home Mechanical Ventilation of Children in İstanbul [PDF]

OBJECTIVE: The aims of this multi-center study were to describe the characteristics of children receiving long-term home mechanical ventilation (HMV) in İstanbul and to compare the patients receiving non-invasive and invasive ventilation.
Uyan, Zeynep Seda, Azer Kılıç Başkan, Cokugras, Haluk, Emine Atağ, Mürüvvet Yanaz, Hakan Yazan, Yanaz, Muruvvet, Hanife Büşra Küçük, KARADAĞ, BÜLENT TANER, Ebru Köstereli, Refika Ersu, AY, NADİYE PINAR, Uzuner, Selcuk, GÖKDEMİR, YASEMİN, Zeynep Reyhan Onay, Aslınur Soyyiğit, Yazan, Hakan, Saniye Girit, Yetkin Ayhan, Ersu, Refika, Aynur Gulieva, Nilay Baş İkizoğlu, Bülent Karadağ, Oktem, Sedat, Erkan Çakır, KILINÇ SAKALLI, AYŞE AYZIT, YILMAZ YEĞİT, CANSU, Füsun Ünal, Sedat Öktem, Ayhan, Yetkin, Evrim Hepkaya, Selçuk Uzuner, Kucuk, Hanife Busra, Soyyigit, Aslinur, Karakoc, Fazilet, Atag, Emine, Kalyoncu, Mine, Ela Erdem Eralp, Unal, Fusun, Mine Kalyoncu, Gulieva, Aynur, Fazilet Karakoç, ERGENEKON, ALMALA PINAR, Hepkaya, Evrim, Ikizoglu, Nilay Bas, Haluk Çokuğraş, REYHAN ONAY, ZEYNEP, Zeynep Seda Uyan, Cansu Yılmaz Yeğit, Almala Pınar Ergenekon, Sinem Can Oksay, Kostereli, Ebru, GİRİT, SANİYE, Ayşe Ayzıt Kılınç, Pınar Ay, Baskan, Azer Kilic, Oksay, Sinem Can, ERDEM ERALP, ELA, Cakir, Erkan   +58 more
core   +1 more source

Predicting Duration of Invasive Mechanical Ventilation in the Pediatric ICU

, 2023
Background: Timely ventilator liberation can prevent morbidities associated with invasive mechanical ventilation in the pediatric ICU (PICU). There currently exists no standard benchmark for duration of invasive mechanical ventilation in the PICU.
Abu-Sultaneh, Samer, Loberger, Jeremy M., Colin M Rogerson, Ross, Patrick, Jeremy M Loberger, Samer Abu-Sultaneh, L Nelson Sanchez-Pinto, Rogerson, Colin M., Robinder G Khemani, Sanchez-Pinto, L. Nelson, Patrick Ross, Khemani, Robinder G.   +11 more
core   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Preserving Motor Features by Alternative Re‐Referencing to Remove Heart Artifact on the Stentrode

Advanced Science, EarlyView.
Endovascular brain‐computer interfaces record neural activity from within cerebrovasculature, at the expense of electrocardiogram contamination. Band‐limited independent component analysis separates this heart‐based artifact from task‐relevant neural activity in each frequency band, enabling the reconstruction of cleaner neural recordings without the ...
Ariel K. Feldman, Kriti Kacker, Rahyun Yun, Nikole Chetty, James Bennett, Peter E. Yoo, Raul G. Nogueira, Jennifer L. Collinger, Nicholas L. Opie, Thomas J. Oxley, David F. Putrino, Douglas J. Weber   +11 more
wiley   +1 more source