Results 71 to 80 of about 3,508,285 (256)
Mechanical Ventilation in Brain Injured Patients
, 2022 Mechanical ventilation is a cornerstone in the management of patients with brain injury, since these patients are often unable to protect airways and they require a careful management of oxygenation and carbon dioxide.
Peluso, Lorenzo +6 more
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Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer
Advanced Science, EarlyView.Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang +17 more
wiley +1 more source
Summary of results for the primary outcome (death or invasive mechanical ventilation at day 28).
, 2023 Heterogeneity for COPD severity subgroups: Chi2 = 3.50, df = 2, p = 0.32. Heterogeneity for ventilatory support subgroups: Chi2 = 6.36, df = 2, p = 0.10. Heterogeneity for SAPS II subgroups: Chi2 = 5,26, df = 1, p = 0.15.
Louis Marie Galerneau (14334189) +21 more
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Advanced Science, EarlyView.This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei +17 more
wiley +1 more source
Calculating the work of breathing during mechanical ventilation
, 2021 Left figure: Passive patient esophageal pressure (Pes) in cmH2O on x-axis versus tidal volume in ml on y-axis. Green dashed line represents the chest wall compliance Right figure: same patient actively breathing on pressure support ventilation. (Pes) in
Mia Shokry +3 more
core +1 more source
Advanced Science, EarlyView.A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang +18 more
wiley +1 more source
STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis
Advanced Science, EarlyView.STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen +19 more
wiley +1 more source
Advanced Science, EarlyView.An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu +10 more
wiley +1 more source
Mechanical ventilation : clinical applications and pathophysiology /
, 2008 One of the key tools in effectively managing critical illness is the use of mechanical ventilator support. This essential text helps you navigate this rapidly evolving technology and understand the latest research and treatment modalities.
Lachmann, Burkhard., Papadakos, Peter.
core
The Role of Non-Invasive Ventilation and Factors Predicting Extubation Outcome in Myasthenic Crisis
, 2011 INTRODUCTION: Myasthenic crisis is a great threat to patients with myasthenia gravis. Usage of non-invasive ventilation (NIV) to prevent intubation and timing of extubating of patients in myasthenic crisis are important issues though not well documented.
巫震宇;郭炳宏;范碧娟;吳惠東;石富元;楊泮池 +1 more
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