Genetic susceptibility to aspergillosis in allogeneic stem-cell transplantation [PDF]
Invasive aspergillosis (IA) is a major threat to positive outcomes for allogeneic stem-cell transplantation (allo-SCT) patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop infection. Therefore,
Agostinho Carvalho +48 more
core +1 more source
Acute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report
A 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and radiological examinations suggested an acute exacerbation of chronic obstructive pulmonary disease.
Yuuki Ohara +4 more
doaj +1 more source
ACR Open Rheumatology, Volume 8, Issue 4, April 2026.
Leonardo Rodrigues Campos +6 more
wiley +1 more source
Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song +10 more
wiley +1 more source
Acute respiratory failure in patients with hematological malignancies : outcomes according to initial ventilation strategy : a Groupe de recherche respiratoire en réanimation onco-hématologique (Grrr-OH) study [PDF]
Background: In patients with hematological malignancies and acute respiratory failure (ARF), noninvasive ventilation was associated with a decreased mortality in older studies. However, mortality of intubated patients decreased in the last years. In this
Azoulay, Elie +14 more
core +2 more sources
Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill.
Jessica D. Workum +7 more
doaj +1 more source
Fungal systematics can feel overwhelming given the vast species diversity within this kingdom, with numerous subgroups at every taxonomic rank. This often creates a disconnect between the undertsnidng of fungal taxonomic diversity and their societal relevance.
Anna Vaiana +4 more
wiley +1 more source
Studies on the release of neutrophil extracellular traps and IFN-γ as part of the innate immune response to Aspergillus fumigatus and on the fungal stress response via the hybrid sensor kinase TcsC [PDF]
Aspergillus fumigatus is a saprophytic mold that naturally inhabits the soil. Asexual reproduction yields hardy conidia that circulate in the air and are inhaled daily by humans.
McCormick, Allison
core
Immunogenetic profiling to predict risk of invasive fungal diseases : where are we now? [PDF]
Invasive fungal diseases remain nowadays life-threatening conditions affecting multiple clinical settings. The onset of these diseases is dependent on numerous factors, of which the "immunocompromised" phenotype of the patients is the more often ...
Aversa, Franco +6 more
core +1 more source
Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses [PDF]
Cryptococcus neoformans is the most common disseminated fungal pathogen in AIDS patients, resulting in ∼200,000 deaths each year. There is a pressing need for new treatments for this infection, as current antifungal therapy is hampered by toxicity and/or
Hole, Camaron R +3 more
core +2 more sources

