Results 51 to 60 of about 1,975,778 (285)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A PERISHABLE INVENTORY MODEL WITH UNKNOWN TIME HORIZON [PDF]
, 2008 Traditionally, the time (planning) horizon over which the inventory for a particular item will be controlled is often assumed to be known (finite or infinite) and the total inventory cost is usually obtained by summing up the cost over the entire time ...
A.E., OLULEYE +2 more
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Stand Regeneration Characteristics of Beech and Fir Forests in Gorski Kotar Region
South-East European Forestry, 2016 Background and Purpose: Beech-fir forests cover about 13% of forest land in Croatia, thus being a significant forest resource that is dominantly managed by uneven-aged selection management system.
Krunoslav Teslak +4 more
doaj +1 more source
Notulae Scientia Biologicae, 2020 The forest in India have a long history of human induced modifications through intensive forest management that began in the colonial period but continued afterwards to meet the wood-based demand until the forestry goals shifted towards conservation ...
Arun K. THAKUR +2 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Expanded description and distribution of Opisthotropis tamdaoensis Ziegler, David & Vu, 2008 (Squamata, Natricidae), first record from Yunnan Province of China [PDF]
Biodiversity Data JournalThe Tam Dao Mountain Stream Keelback, Opisthotropis tamdaoensis Ziegler, David & Vu, 2008, was previously described, based on one single holotype and subsequently expanded according to four newly-collected specimens from the type locality ...
Siyuan Zhao +7 more
doaj +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source