Results 71 to 80 of about 694,399 (289)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Chiral radiative corrections in potential model and the P-wave states of heavy-light mesons

, 2008
In relativistic potential model of heavy-light mesons it is essential to incorporate the chiral radiative corrections before comparing the model predictions with data.
Lee, Taekoon
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Modeling of Alpine Grassland Cover Based on Unmanned Aerial Vehicle Technology and Multi-Factor Methods: A Case Study in the East of Tibetan Plateau, China

Remote Sensing, 2018
Grassland cover and its temporal changes are key parameters in the estimation and monitoring of ecosystems and their functions, especially via remote sensing.
Baoping Meng, Jinlong Gao, Tiangang Liang, Xia Cui, Jing Ge, Jianpeng Yin, Qisheng Feng, Hongjie Xie   +7 more
doaj   +1 more source

Investigation of strongly ducted infrasonic dispersion using a vertical eigenfunction expansion of the Helmholtz equation in a modal broad band acoustic propagation code [PDF]

, 2015
Master's Project (M.S.) University of Alaska Fairbanks, 2015This study investigates an infrasound propagation model created by the National Center for Physical Acoustics (NCPA) which is applied to atmospheric data with a strong temperature inversion in ...
Edon, Robert Alexander
core  

A procedure for the inversion of f-mode travel times for solar flows

, 2007
We perform a two-dimensional inversion of f-mode travel times to determine near-surface solar flows. The inversion is based on optimally localized averaging of travel times. We use finite-wavelength travel-time sensitivity functions and a realistic model
Birch, Christensen-Dalsgaard, Duvall, Duvall, Duvall, Gizon, Gizon, Hansen, Hansen, Jackiewicz, Pijpers, Pijpers   +11 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Comparison of Seven Inversion Models for Estimating Plant and Woody Area Indices of Leaf-on and Leaf-off Forest Canopy Using Explicit 3D Forest Scenes

Remote Sensing, 2018
Optical methods require model inversion to infer plant area index (PAI) and woody area index (WAI) of leaf-on and leaf-off forest canopy from gap fraction or radiation attenuation measurements.
Jie Zou, Yinguo Zhuang, Francesco Chianucci, Chunna Mai, Weimu Lin, Peng Leng, Shezhou Luo, Bojie Yan   +7 more
doaj   +1 more source

Semi-empirical model of MOST and passive devices focused on narrowband RF blocks [PDF]

, 2012
This paper presents a semi-empirical modeling of MOST and passive elements to be used in narrowband radiofrequency blocks for nanometer technologies. This model is based on a small set of look-up tables (LUTs) obtained via electrical simulations.
Fiorelli, Rafaella, Peralías Macías, Eduardo, Rueda Rueda, Adoración, Silveira Noguerol, Fernando   +3 more
core  

Application of the $\chi^2$ principle and unbiased predictive risk estimator for determining the regularization parameter in 3D focusing gravity inversion

, 2014
The $\chi^2$ principle and the unbiased predictive risk estimator are used to determine optimal regularization parameters in the context of 3D focusing gravity inversion with the minimum support stabilizer. At each iteration of the focusing inversion the
Ardestani, Vahid E., Renaut, Rosemary A., Vatankhah, Saeed   +2 more
core   +1 more source