Results 61 to 70 of about 694,399 (289)

Estimation of poroelastic parameters from seismograms using Biot theory [PDF]

, 2009
We investigate the possibility to extract information contained in seismic waveforms propagating in fluid-filled porous media by developing and using a full waveform inversion procedure valid for layered structures.
De Barros, Louis, Dietrich, Michel
core   +2 more sources

Time-Reversal Symmetry-Breaking Nematic Insulators near Quantum Spin Hall Phase Transitions

, 2018
We study the phase diagram of a model quantum spin Hall system as a function of band inversion and band-coupling strength, demonstrating that when band hybridization is weak, an interaction-induced nematic insulator state emerges over a wide range of ...
Akira Ishihama (218938), Kan Tanaka (11731), Tomohiro Shimada (218931)   +2 more
core   +3 more sources

Multiscale Modelling and Inverse Problems [PDF]

, 2011
Submitted to the proceedings of the summer school "Numerical Analysis of Multiscale Problems", edited by I.G. Graham, T.Y. Hou, O. Lakkis and R. Scheichl.
Nolen, James, Pavliotis, Grigorios A., Stuart, Andrew M.   +2 more
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

MODEL SELECTION FOR SPECTROPOLARIMETRIC INVERSIONS [PDF]

The Astrophysical Journal, 2012
16 pages, 2 figures, 8 tables, accepted for publication in ...
Ramos, A. Asensio, Sainz, R. Manso, Gonzalez, M. J. Martinez, Viticchie, B., Suarez, D. Orozco, Socas-Navarro, H.   +5 more
openaire   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Coupling ecological concepts with an ocean-colour model: inversion modelling

Frontiers in Remote Sensing
Monitoring phytoplankton from space can help detect shifts in marine ecosystems, particularly under accelerating climate change. However, most existing ocean-colour chlorophyll-a (Chl-a) algorithms are empirical in nature, and do not explicitly consider ...
Xuerong Sun, Robert J. W. Brewin, Shubha Sathyendranath, Shubha Sathyendranath, Giorgio Dall’Olmo, David Antoine, David Antoine, Ray Barlow, Astrid Bracher, Astrid Bracher, Malika Kheireddine, Mengyu Li, Jaime Pitarch, Dionysios E. Raitsos, Fang Shen, Gavin H. Tilstone, Vincenzo Vellucci, Vincenzo Vellucci, Yuan Zhang   +18 more
doaj   +1 more source

When Darwin Met Einstein: Gravitational Lens Inversion with Genetic Algorithms

, 2005
Gravitational lensing can magnify a distant source, revealing structural detail which is normally unresolvable. Recovering this detail through an inversion of the influence of gravitational lensing, however, requires optimisation of not only lens ...
Bailer-Jones, Bobinger, Brendon J. Brewer, Cohen, Darwin, Dye, Geraint F. Lewis, Gómez de Castro, Hakala, Kochanek, Levy, Press, Wayth   +12 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source