Results 51 to 60 of about 6,761 (247)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Influence of Measurement Methodology on the Accuracy of Electrical Waveform Distortion Analysis

Measurement Science Review, 2018
The present paper covers a review of documents that specify measurement methods of voltage waveform distortion. It also presents measurement stages of waveform components that are uncommon in the classic fundamentals of electrotechnics and signal theory,
Bartman Jacek, Kwiatkowski Bogdan
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Discrete Adaptive Nonswitching Reaching Law Algorithm for Sliding Mode Control of a Grid-Following Inverter

Energies
This paper extends one of the nonswitching-type reaching laws for discrete-time sliding mode control. The control task under consideration is the regulation of the grid current of the grid-following power inverter.
Albert Sawiński, Piotr Leśniewski, Piotr Chudzik   +2 more
doaj   +1 more source

A New Single-Stage Three-Phase PFC for Four-Switch Three-Phase Inverter Fed IM Drives

Advances in Electrical and Computer Engineering, 2019
This paper proposes a single-stage three-phase power factor correction (PFC) for four-switch inverter (FSI) fed induction motor (IM) drives. The PFC scheme uses a Cuk converter with only one switch, and consequently, it needs only one control signal ...
ZAKY, M., FETOUH, T., AZAZI, H.
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Implementing Wireless Charging System for Semi-Autonomous Agricultural Robots

Energies
The modernization of agriculture can help humanity address major challenges such as population growth, climate change, and labor shortages. Semi-autonomous agricultural robots offer clear advantages in automating tasks and improving efficiency.
Abdoulaye Bodian, Alben Cardenas, Dina Ouardani, Jaber Ouakrim, Afef Bennani-Ben Abdelghani   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Output Impedance Control Method of Inverter-Based Distributed Generators for Autonomous Microgrid

Energies, 2017
The droop method is the most favorable alternative in microgrid implementations for autonomous control of grid-forming inverter-based distributed generators (DGs) connected in parallel. However, the dynamic characteristic of the conventional droop method
Youn-Ok Choi, Jaehong Kim
doaj   +1 more source