Results 11 to 20 of about 743,546 (262)
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Ética e investigación biomédica [PDF]
Nómadas, 2000 Se hacen algunas consideraciones de carácter ético acerca de la ciencia y su cultor, el científico. La investigación biomédica, que toca directamente con los intereses más valiosos del hombre –su vida y su salud– tiene alcances fácticos de tanta ...
Fernando Sánchez Torres
doaj +2 more sources
Functionalization and Characterization of Magnetic Nanoparticles for the Detection of Ferritin Accumulation in Alzheimer's Disease [PDF]
, 2018 Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that lead to dementia and death.
Cussó, Lorena +4 more
core +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice
Nature Communications, 2022 Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of ...
Juan Roa +18 more
doaj +1 more source
El marco normativo de la investigación biomédica en personas con demencia
, 2020 espanolLa demencia es una de las mayores causas de discapacidad y dependencia a nivel mundial, con consecuencias perjudiciales de caracter fisico, psicologico, social, economico.
J. Seoane, Natalia Álvarez Lata
semanticscholar +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
ARS Medica, 2006 En el presente artículo, analizaremos en profundidad los desafíos éticos que plantea la investigación biomédica que se realiza en países en vías de desarrollo, especialmente cuando esta es planeada, ejecutada y/o financiada por investigadores o empresas ...
Sofía Salas Ibarra
doaj +1 more source
La acreditación de los comités de ética de la investigación
Gaceta Sanitaria, 2017 Objetivo: Según la Ley 14/2007 y el Real Decreto 1090/2015, la investigación biomédica debe ser evaluada por un comité de ética de la investigación (CEI), que deberá estar acreditado como comité de ética de la investigación con medicamentos (CEIm) si el ...
Miguel A. Ramiro Avilés
doaj +1 more source