Results 21 to 30 of about 4,071,660 (220)
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice
Nature Communications, 2022 Kiss1 neurons are essential for puberty and fertility. Here, the authors show that canonical microRNA biosynthesis in Kiss1 neurons plays an essential role in the control of puberty and fertility, especially in females, likely via repression of ...
Juan Roa +18 more
doaj +1 more source
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
La acreditación de los comités de ética de la investigación
Gaceta Sanitaria, 2017 Objetivo: Según la Ley 14/2007 y el Real Decreto 1090/2015, la investigación biomédica debe ser evaluada por un comité de ética de la investigación (CEI), que deberá estar acreditado como comité de ética de la investigación con medicamentos (CEIm) si el ...
Miguel A. Ramiro Avilés
doaj +1 more source
Antioxidants, 2023 Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic liver disease (ALD).
Daniel Salete-Granado +6 more
doaj +1 more source
Estudios de Deusto, 2014 La Ley 14/2007 de 3 de Julio, de investigación biomédica (LIB), reconoce que la investigación biomédica y las ciencias de la salud son instrumentos esenciales para mejorar la calidad y la esperanza de vida de las personas, y para incrementar su bienestar.
Sergio Romeo Malanda
doaj +1 more source
Biomedicines, 2022 Several biologic therapies that target inflammatory modulators are now used for treating patients with uncontrolled, severe asthma. Knowledge about how this type of treatment modifies the molecular milieu is rapidly increasing.
Maria J. Martin +6 more
doaj +1 more source
Low Activation of CD8+ T Cells in response to Viral Peptides in Mexican Patients with Severe Dengue
Journal of Immunology Research, 2022 It is acknowledged that antiviral immune response contributes to dengue immunopathogenesis. To identify immunological markers that distinguish dengue fever (DF) and dengue hemorrhagic fever (DHF), 113 patients with confirmed dengue infection were ...
Tania Estrada-Jiménez +6 more
doaj +1 more source