Results 11 to 20 of about 110,805 (249)
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis
Hepatology, EarlyView., 2022 Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres +21 more
wiley +1 more source
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma [PDF]
, 2019 This work was supported by grants from the Plan Nacional de I + D + I cofinanced by the ISCIII-Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER), PI12/1832, the Spanish Association for Cancer Research (AECC), and ...
Astudillo, Aurora +11 more
core +2 more sources
Estudios de Deusto, 2014 La Ley 14/2007 de 3 de Julio, de investigación biomédica (LIB), reconoce que la investigación biomédica y las ciencias de la salud son instrumentos esenciales para mejorar la calidad y la esperanza de vida de las personas, y para incrementar su bienestar.
Sergio Romeo Malanda
doaj +1 more source
Low Activation of CD8+ T Cells in response to Viral Peptides in Mexican Patients with Severe Dengue
Journal of Immunology Research, 2022 It is acknowledged that antiviral immune response contributes to dengue immunopathogenesis. To identify immunological markers that distinguish dengue fever (DF) and dengue hemorrhagic fever (DHF), 113 patients with confirmed dengue infection were ...
Tania Estrada-Jiménez +6 more
doaj +1 more source
La investigación y educación biomédica en el Perú
Horizonte Médico, 2019 Con el Reglamento de Instrucción Pública de 1855 a inicios La República, que establecía tres grados de instrucción pública y gratuita desde los primeros grados de instrucción básica hasta la universitaria, se conseguía el retorno de los estudios médicos ...
Frank Lizaraso Caparó +1 more
doaj +1 more source
Revista Española de Documentación Científica, 1992 El presente estudio es un análisis de la participación de los investigadores de la UNAM en la literatura biomédica internacional. Tiene por objeto determinar aquellas áreas de la investigación biomédica donde la UNAM es más activa, así como evaluar la ...
Jane M. Russell +3 more
doaj +1 more source